Gene3D: Extensive prediction of globular domains in proteins

Tony E Lewis, Ian Sillitoe, Natalie Dawson, Su Datt Lam, Tristan Clarke, David Lee, Christine Orengo, Jonathan Lees

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)
237 Downloads (Pure)

Abstract

Gene3D (http://gene3d.biochem.ucl.ac.uk) is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains. Amongst other updates, we have added visualization tools for exploring domain annotations in the context of other sequence features and in gene families. We also provide web-pages to visualize other domain families that co-occur with a given query domain family.

Original languageEnglish
Pages (from-to)D435-D439
JournalNucleic Acids Research
Volume46
Issue numberD1
DOIs
Publication statusPublished - 4 Jan 2018

Keywords

  • Journal Article

Fingerprint Dive into the research topics of 'Gene3D: Extensive prediction of globular domains in proteins'. Together they form a unique fingerprint.

  • Cite this

    Lewis, T. E., Sillitoe, I., Dawson, N., Lam, S. D., Clarke, T., Lee, D., Orengo, C., & Lees, J. (2018). Gene3D: Extensive prediction of globular domains in proteins. Nucleic Acids Research, 46(D1), D435-D439. https://doi.org/10.1093/nar/gkx1069, https://doi.org/10.1093/nar/gkx1069