Gene3D: Extensive prediction of globular domains in proteins

Tony E Lewis, Ian Sillitoe, Natalie Dawson, Su Datt Lam, Tristan Clarke, David Lee, Christine Orengo, Jonathan Lees

Research output: Contribution to journalArticle (Academic Journal)peer-review

41 Citations (Scopus)
229 Downloads (Pure)


Gene3D ( is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains. Amongst other updates, we have added visualization tools for exploring domain annotations in the context of other sequence features and in gene families. We also provide web-pages to visualize other domain families that co-occur with a given query domain family.

Original languageEnglish
Pages (from-to)D435-D439
JournalNucleic Acids Research
Issue numberD1
Publication statusPublished - 4 Jan 2018


  • Journal Article

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