General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

S C Lewis; C P Warlow; A R Bodenham; B Colam; P M Rothwell; D Torgerson; D Dellagrammaticas; M Horrocks; C Liapis; A P Banning; M Gough; M J Gough; GALA Trial Collaborative Group; Frank C T Smith

doi:10.1016/S0140-6736(08)61699-2

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

S C Lewis, C P Warlow, A R Bodenham, B Colam, P M Rothwell, D Torgerson, D Dellagrammaticas, M Horrocks, C Liapis, A P Banning, M Gough, M J Gough, GALA Trial Collaborative Group, Frank C T Smith

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia.

Original language	English
Pages (from-to)	2132-42
Number of pages	11
Journal	Lancet
Volume	372
Issue number	9656
DOIs	https://doi.org/10.1016/S0140-6736(08)61699-2
Publication status	Published - 20 Dec 2008

Keywords

Aged
Anesthesia, General
Anesthesia, Local
Carotid Stenosis
Endarterectomy, Carotid
Female
Humans
Male
Postoperative Complications
Stroke

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Lewis, S. C., Warlow, C. P., Bodenham, A. R., Colam, B., Rothwell, P. M., Torgerson, D., Dellagrammaticas, D., Horrocks, M., Liapis, C., Banning, A. P., Gough, M., Gough, M. J., GALA Trial Collaborative Group, & Smith, F. C. T. (2008). General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet, 372(9656), 2132-42. https://doi.org/10.1016/S0140-6736(08)61699-2

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abstract = "The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia.",

keywords = "Aged, Anesthesia, General, Anesthesia, Local, Carotid Stenosis, Endarterectomy, Carotid, Female, Humans, Male, Postoperative Complications, Stroke",

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Lewis, SC, Warlow, CP, Bodenham, AR, Colam, B, Rothwell, PM, Torgerson, D, Dellagrammaticas, D, Horrocks, M, Liapis, C, Banning, AP, Gough, M, Gough, MJ, GALA Trial Collaborative Group & Smith, FCT 2008, 'General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial', Lancet, vol. 372, no. 9656, pp. 2132-42. https://doi.org/10.1016/S0140-6736(08)61699-2

TY - JOUR

T1 - General anaesthesia versus local anaesthesia for carotid surgery (GALA)

T2 - a multicentre, randomised controlled trial

AU - Lewis, S C

AU - Warlow, C P

AU - Bodenham, A R

AU - Colam, B

AU - Rothwell, P M

AU - Torgerson, D

AU - Dellagrammaticas, D

AU - Horrocks, M

AU - Liapis, C

AU - Banning, A P

AU - Gough, M

AU - Gough, M J

AU - GALA Trial Collaborative Group

AU - Smith, Frank C T

PY - 2008/12/20

Y1 - 2008/12/20

N2 - The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia.

AB - The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia.

KW - Aged

KW - Anesthesia, General

KW - Anesthesia, Local

KW - Carotid Stenosis

KW - Endarterectomy, Carotid

KW - Female

KW - Humans

KW - Male

KW - Postoperative Complications

KW - Stroke

U2 - 10.1016/S0140-6736(08)61699-2

DO - 10.1016/S0140-6736(08)61699-2

M3 - Article (Academic Journal)

C2 - 19041130

SN - 0140-6736

VL - 372

SP - 2132

EP - 2142

JO - Lancet

JF - Lancet

IS - 9656

ER -

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

Abstract

Keywords

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