Generation and Regulation of Spontaneous Contractions in the Prostate

B Chakrabarty, S Lee, B Exintaris

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Abstract

Spontaneous myogenic contractions have been shown to be significantly upregulated in prostate tissue collected from men with Benign Prostatic Hyperplasia (BPH), an extremely common disorder of the ageing male. Although originally thought likely to be involved in 'housekeeping' functions, mixing prostatic secretions to prevent stagnation, these spontaneous myogenic contractions provide a novel opportunity to understand and treat BPH. This treatment potential differs from previous models, which focused exclusively on attenuating nerve-mediated neurogenic contractions. Previous studies in the rodent prostate have provided an insight into the mechanisms underlying the regulation of myogenic contractions. 'Prostatic Interstitial Cells' (PICs) within the prostate appear to generate pacemaker potentials, which arise from the summation of number of spontaneous transient depolarisations triggered by the spontaneous release of Ca2+ from internal stores and the opening of Ca2+-activated Cl- channels. Pacemaker potentials then conduct into neighbouring smooth muscle cells to generate spontaneous slow waves. These slow waves trigger the firing of 'spike-like' action potentials, Ca2+ entry and contraction, which are not attenuated by blockers of neurotransmission. However, these spontaneous prostatic contractions can be modulated by the autonomic nervous system. Here, we discuss the mechanisms underlying rodent and human prostate myogenic contractions and the actions of existing and novel pharmacotherapies for the treatment of BPH. Understanding the generation of human prostatic smooth muscle tone will confirm the mechanism of action of existing drugs, inform the identification and effectiveness of new pharmacotherapies, as well as predict patient outcomes.
Original languageEnglish
Title of host publicationSmooth Muscle Spontaneous Activity
PublisherSpringer Nature
Pages 195-215
Volume1124
ISBN (Electronic)978-981-13-5895-1
ISBN (Print)978-981-13-5894-4
DOIs
Publication statusPublished - 11 Jan 2019

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer Verlag
ISSN (Print)0065-2598

Fingerprint Dive into the research topics of 'Generation and Regulation of Spontaneous Contractions in the Prostate'. Together they form a unique fingerprint.

  • Cite this

    Chakrabarty, B., Lee, S., & Exintaris, B. (2019). Generation and Regulation of Spontaneous Contractions in the Prostate. In Smooth Muscle Spontaneous Activity (Vol. 1124, pp. 195-215). (Advances in Experimental Medicine and Biology). Springer Nature. https://doi.org/10.1007/978-981-13-5895-1_8