TY - JOUR
T1 - Genes and evolution of two-domain toxins from lynx spider venom.
AU - Sachkova, MY
AU - Slavokhotova, Anna
AU - Grishin, EV
AU - Vassilevski, Alexander
PY - 2014/1/23
Y1 - 2014/1/23
N2 - Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.
AB - Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.
UR - https://doi.org/10.1016/j.febslet.2014.01.018
U2 - 10.1016/j.febslet.2014.01.018
DO - 10.1016/j.febslet.2014.01.018
M3 - Article (Academic Journal)
C2 - 24462682
SN - 0014-5793
JO - FEBS Letters
JF - FEBS Letters
ER -