Genes and evolution of two-domain toxins from lynx spider venom.

MY Sachkova; Anna Slavokhotova; EV Grishin; Alexander Vassilevski

doi:10.1016/j.febslet.2014.01.018

Genes and evolution of two-domain toxins from lynx spider venom.

MY Sachkova, Anna Slavokhotova, EV Grishin, Alexander Vassilevski

School of Biological Sciences

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Abstract

Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.

Original language	English
Journal	FEBS Letters
DOIs	https://doi.org/10.1016/j.febslet.2014.01.018
Publication status	Published - 23 Jan 2014

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title = "Genes and evolution of two-domain toxins from lynx spider venom.",

abstract = "Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.",

author = "MY Sachkova and Anna Slavokhotova and EV Grishin and Alexander Vassilevski",

year = "2014",

month = jan,

day = "23",

doi = "10.1016/j.febslet.2014.01.018",

language = "English",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc",

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TY - JOUR

T1 - Genes and evolution of two-domain toxins from lynx spider venom.

AU - Sachkova, MY

AU - Slavokhotova, Anna

AU - Grishin, EV

AU - Vassilevski, Alexander

PY - 2014/1/23

Y1 - 2014/1/23

N2 - Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.

AB - Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.

UR - https://doi.org/10.1016/j.febslet.2014.01.018

U2 - 10.1016/j.febslet.2014.01.018

DO - 10.1016/j.febslet.2014.01.018

M3 - Article (Academic Journal)

C2 - 24462682

SN - 0014-5793

JO - FEBS Letters

JF - FEBS Letters

ER -

Genes and evolution of two-domain toxins from lynx spider venom.

Abstract

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