Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation

Kellie J Hall, Matthew T Harper, Karen Gilio, Judith M Cosemans, Johan W M Heemskerk, Alastair W Poole

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Abstract

PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive therapeutic target for immune modulation. Collagen is a major agonist for platelets, operating through an immunoreceptor-like signalling pathway from its receptor GPVI. Although it has recently been shown that PKCtheta positively regulates outside-in signalling through integrin alpha(IIb)beta(3) in platelets, the role of PKCtheta in GPVI-dependent signalling and functional activation of platelets has not been assessed.
Original languageEnglish
Pages (from-to)e3277
JournalPLoS ONE
Volume3
Issue number9
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • Autoimmune Diseases
  • Platelet Activation
  • Mice
  • Models, Biological
  • Thrombosis
  • Protein Isoforms
  • Collagen
  • Blood Platelets
  • Platelet Adhesiveness
  • Platelet Aggregation
  • Isoenzymes
  • Mice, Inbred C57BL
  • Gene Expression Regulation
  • Protein Kinase C
  • Immune System

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