Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Katherine Williams; Agnieszka J. Szwalbe; Claire Dickson; Tim R. Desson; Nicholas P. Mulholland; Jason L. Vincent; John M. Clough; Andrew M. Bailey; Craig P. Butts; Christine L. Willis; Thomas J. Simpson; Russell J. Cox

doi:10.1039/c7cc03303f

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Katherine Williams, Agnieszka J. Szwalbe, Claire Dickson, Tim R. Desson, Nicholas P. Mulholland, Jason L. Vincent, John M. Clough, Andrew M. Bailey, Craig P. Butts, Christine L. Willis, Thomas J. Simpson, Russell J. Cox^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

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Abstract

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

Original language	English
Pages (from-to)	7965-7968
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	56
Early online date	23 Jun 2017
DOIs	https://doi.org/10.1039/c7cc03303f
Publication status	Published - 18 Jul 2017

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Williams, K., Szwalbe, A. J., Dickson, C., Desson, T. R., Mulholland, N. P., Vincent, J. L., Clough, J. M., Bailey, A. M., Butts, C. P., Willis, C. L., Simpson, T. J., & Cox, R. J. (2017). Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis. Chemical Communications, 53(56), 7965-7968. https://doi.org/10.1039/c7cc03303f

Williams, Katherine ; Szwalbe, Agnieszka J. ; Dickson, Claire ; Desson, Tim R. ; Mulholland, Nicholas P. ; Vincent, Jason L. ; Clough, John M. ; Bailey, Andrew M. ; Butts, Craig P. ; Willis, Christine L. ; Simpson, Thomas J. ; Cox, Russell J. / Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis. In: Chemical Communications. 2017 ; Vol. 53, No. 56. pp. 7965-7968.

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title = "Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis",

abstract = "The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.",

author = "Katherine Williams and Szwalbe, {Agnieszka J.} and Claire Dickson and Desson, {Tim R.} and Mulholland, {Nicholas P.} and Vincent, {Jason L.} and Clough, {John M.} and Bailey, {Andrew M.} and Butts, {Craig P.} and Willis, {Christine L.} and Simpson, {Thomas J.} and Cox, {Russell J.}",

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Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis. / Williams, Katherine; Szwalbe, Agnieszka J.; Dickson, Claire; Desson, Tim R.; Mulholland, Nicholas P.; Vincent, Jason L.; Clough, John M.; Bailey, Andrew M.; Butts, Craig P.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J.

In: Chemical Communications, Vol. 53, No. 56, 18.07.2017, p. 7965-7968.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Szwalbe, Agnieszka J.

AU - Dickson, Claire

AU - Desson, Tim R.

AU - Mulholland, Nicholas P.

AU - Vincent, Jason L.

AU - Clough, John M.

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AB - The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

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Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

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Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

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