Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Katherine Williams; Agnieszka J. Szwalbe; Claire Dickson; Tim R. Desson; Nicholas P. Mulholland; Jason L. Vincent; John M. Clough; Andrew M. Bailey; Craig P. Butts; Christine L. Willis; Thomas J. Simpson; Russell J. Cox

doi:10.1039/c7cc03303f

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Katherine Williams, Agnieszka J. Szwalbe, Claire Dickson, Tim R. Desson, Nicholas P. Mulholland, Jason L. Vincent, John M. Clough, Andrew M. Bailey, Craig P. Butts, Christine L. Willis, Thomas J. Simpson, Russell J. Cox^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

Original language	English
Pages (from-to)	7965-7968
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	56
Early online date	23 Jun 2017
DOIs	https://doi.org/10.1039/c7cc03303f
Publication status	Published - 18 Jul 2017

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Williams, K., Szwalbe, A. J., Dickson, C., Desson, T. R., Mulholland, N. P., Vincent, J. L., Clough, J. M., Bailey, A. M., Butts, C. P., Willis, C. L., Simpson, T. J., & Cox, R. J. (2017). Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis. Chemical Communications, 53(56), 7965-7968. https://doi.org/10.1039/c7cc03303f

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title = "Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis",

abstract = "The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.",

author = "Katherine Williams and Szwalbe, {Agnieszka J.} and Claire Dickson and Desson, {Tim R.} and Mulholland, {Nicholas P.} and Vincent, {Jason L.} and Clough, {John M.} and Bailey, {Andrew M.} and Butts, {Craig P.} and Willis, {Christine L.} and Simpson, {Thomas J.} and Cox, {Russell J.}",

year = "2017",

month = jul,

day = "18",

doi = "10.1039/c7cc03303f",

language = "English",

volume = "53",

pages = "7965--7968",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

AU - Williams, Katherine

AU - Szwalbe, Agnieszka J.

AU - Dickson, Claire

AU - Desson, Tim R.

AU - Mulholland, Nicholas P.

AU - Vincent, Jason L.

AU - Clough, John M.

AU - Bailey, Andrew M.

AU - Butts, Craig P.

AU - Willis, Christine L.

AU - Simpson, Thomas J.

AU - Cox, Russell J.

PY - 2017/7/18

Y1 - 2017/7/18

N2 - The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

AB - The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

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U2 - 10.1039/c7cc03303f

DO - 10.1039/c7cc03303f

M3 - Article (Academic Journal)

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AN - SCOPUS:85023756550

VL - 53

SP - 7965

EP - 7968

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 56

ER -

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

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Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

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