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Abstract
The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.
Original language | English |
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Pages (from-to) | 7965-7968 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 53 |
Issue number | 56 |
Early online date | 23 Jun 2017 |
DOIs | |
Publication status | Published - 18 Jul 2017 |
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Dive into the research topics of 'Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis'. Together they form a unique fingerprint.Projects
- 3 Finished
Profiles
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Professor Craig P Butts
- School of Chemistry - Professor of Structural and Mechanistic Chemistry
- Supramolecular and Mechanistic Chemistry
- Spectroscopy and Dynamics
Person: Academic , Member