Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Katherine Williams, Agnieszka J. Szwalbe, Claire Dickson, Tim R. Desson, Nicholas P. Mulholland, Jason L. Vincent, John M. Clough, Andrew M. Bailey, Craig P. Butts, Christine L. Willis, Thomas J. Simpson, Russell J. Cox*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)
324 Downloads (Pure)

Abstract

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

Original languageEnglish
Pages (from-to)7965-7968
Number of pages4
JournalChemical Communications
Volume53
Issue number56
Early online date23 Jun 2017
DOIs
Publication statusPublished - 18 Jul 2017

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