Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics

Ulla Sovio, Amanda J. Bennett, Iona Y. Millwood, John Molitor, Paul F. O'Reilly, Nicholas J. Timpson, Marika Kaakinen, Jaana Laitinen, Jari Haukka, Demetris Pillas, Ioanna Tzoulaki, Jassy Molitor, Clive Hoggart, Lachlan J. M. Coin, John Whittaker, Anneli Pouta, Anna-Liisa Hartikainen, Nelson B. Freimer, Elisabeth Widen, Leena PeltonenPaul Elliott, Mark I. McCarthy, Marjo-Riitta Jarvelin

Research output: Contribution to journalArticle (Academic Journal)peer-review

102 Citations (Scopus)

Abstract

Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with adult height (p
Original languageEnglish
Pages (from-to)e1000409
JournalPLoS Genetics
Volume5
Issue number3
DOIs
Publication statusPublished - 2009

Bibliographical note

M1 - 3

Sovio U Bennett AJ Millwood IY Molitor J O'Reilly PF Timpson NJ Kaakinen M Laitinen J Haukka J Pillas D Tzoulaki I Hoggart C Coin LJ Whittaker J Pouta A Hartikainen AL Freimer NB Widen E Peltonen L Elliott P McCarthy MI Jarvelin MR 1RL1MH083268-01 (United States NIMH NIH HHS) 5R01HL087679-02 (United States NHLBI NIH HHS) G0500539 (United Kingdom Medical Research Council) G0600705 (United Kingdom Medical Research Council) GR069224 (United Kingdom Wellcome Trust)

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