Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics

Ulla Sovio; Amanda J. Bennett; Iona Y. Millwood; John Molitor; Paul F. O'Reilly; Nicholas J. Timpson; Marika Kaakinen; Jaana Laitinen; Jari Haukka; Demetris Pillas; Ioanna Tzoulaki; Jassy Molitor; Clive Hoggart; Lachlan J. M. Coin; John Whittaker; Anneli Pouta; Anna-Liisa Hartikainen; Nelson B. Freimer; Elisabeth Widen; Leena Peltonen; Paul Elliott; Mark I. McCarthy; Marjo-Riitta Jarvelin

doi:10.1371/journal.pgen.1000409

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics

Ulla Sovio, Amanda J. Bennett, Iona Y. Millwood, John Molitor, Paul F. O'Reilly, Nicholas J. Timpson, Marika Kaakinen, Jaana Laitinen, Jari Haukka, Demetris Pillas, Ioanna Tzoulaki, Jassy Molitor, Clive Hoggart, Lachlan J. M. Coin, John Whittaker, Anneli Pouta, Anna-Liisa Hartikainen, Nelson B. Freimer, Elisabeth Widen, Leena PeltonenPaul Elliott, Mark I. McCarthy, Marjo-Riitta Jarvelin

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

135 Citations (Scopus)

Abstract

Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with adult height (p

Original language	English
Pages (from-to)	e1000409
Journal	PLOS Genetics
Volume	5
Issue number	3
DOIs	https://doi.org/10.1371/journal.pgen.1000409
Publication status	Published - 2009

Bibliographical note

M1 - 3

Sovio U Bennett AJ Millwood IY Molitor J O'Reilly PF Timpson NJ Kaakinen M Laitinen J Haukka J Pillas D Tzoulaki I Hoggart C Coin LJ Whittaker J Pouta A Hartikainen AL Freimer NB Widen E Peltonen L Elliott P McCarthy MI Jarvelin MR 1RL1MH083268-01 (United States NIMH NIH HHS) 5R01HL087679-02 (United States NHLBI NIH HHS) G0500539 (United Kingdom Medical Research Council) G0600705 (United Kingdom Medical Research Council) GR069224 (United Kingdom Wellcome Trust)

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http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19266077 http://linkserver.bristol.ac.uk:9003/prod?sid=OVID:medline&id=pmid:19266077&id=doi:&issn=1553-7390&isbn=&volume=5&issue=3&spage=e1000409&pages=e1000409&date=2009&title=PLoS+Genetics&atitle=Genetic+determinants+of+height+growth+assessed+longitudinally+from+infancy+to+adulthood+in+the+northern+Finland+birth+cohort+1966.&aulast=Sovio&pid=%3Cauthor%3ESovio+U%3C%2Fauthor%3E%3CAN%3E19266077%3C%2FAN%3E%3CDT%3EJournal+Article%3C%2FDT%3E

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Sovio, U., Bennett, A. J., Millwood, I. Y., Molitor, J., O'Reilly, P. F., Timpson, N. J., Kaakinen, M., Laitinen, J., Haukka, J., Pillas, D., Tzoulaki, I., Molitor, J., Hoggart, C., Coin, L. J. M., Whittaker, J., Pouta, A., Hartikainen, A.-L., Freimer, N. B., Widen, E., ... Jarvelin, M.-R. (2009). Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics. PLOS Genetics, 5(3), e1000409. https://doi.org/10.1371/journal.pgen.1000409

@article{e1764fcd1e48424dbfc6feea9c134caa,

title = "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics",

abstract = "Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with adult height (p",

author = "Ulla Sovio and Bennett, \{Amanda J.\} and Millwood, \{Iona Y.\} and John Molitor and O'Reilly, \{Paul F.\} and Timpson, \{Nicholas J.\} and Marika Kaakinen and Jaana Laitinen and Jari Haukka and Demetris Pillas and Ioanna Tzoulaki and Jassy Molitor and Clive Hoggart and Coin, \{Lachlan J. M.\} and John Whittaker and Anneli Pouta and Anna-Liisa Hartikainen and Freimer, \{Nelson B.\} and Elisabeth Widen and Leena Peltonen and Paul Elliott and McCarthy, \{Mark I.\} and Marjo-Riitta Jarvelin",

note = "M1 - 3 Sovio U Bennett AJ Millwood IY Molitor J O'Reilly PF Timpson NJ Kaakinen M Laitinen J Haukka J Pillas D Tzoulaki I Hoggart C Coin LJ Whittaker J Pouta A Hartikainen AL Freimer NB Widen E Peltonen L Elliott P McCarthy MI Jarvelin MR 1RL1MH083268-01 (United States NIMH NIH HHS) 5R01HL087679-02 (United States NHLBI NIH HHS) G0500539 (United Kingdom Medical Research Council) G0600705 (United Kingdom Medical Research Council) GR069224 (United Kingdom Wellcome Trust)",

year = "2009",

doi = "10.1371/journal.pgen.1000409",

language = "English",

volume = "5",

pages = "e1000409",

journal = "PLOS Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

number = "3",

}

Sovio, U, Bennett, AJ, Millwood, IY, Molitor, J, O'Reilly, PF, Timpson, NJ, Kaakinen, M, Laitinen, J, Haukka, J, Pillas, D, Tzoulaki, I, Molitor, J, Hoggart, C, Coin, LJM, Whittaker, J, Pouta, A, Hartikainen, A-L, Freimer, NB, Widen, E, Peltonen, L, Elliott, P, McCarthy, MI & Jarvelin, M-R 2009, 'Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics', PLOS Genetics, vol. 5, no. 3, pp. e1000409. https://doi.org/10.1371/journal.pgen.1000409

TY - JOUR

T1 - Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966

T2 - PLoS Genetics

AU - Sovio, Ulla

AU - Bennett, Amanda J.

AU - Millwood, Iona Y.

AU - Molitor, John

AU - O'Reilly, Paul F.

AU - Timpson, Nicholas J.

AU - Kaakinen, Marika

AU - Laitinen, Jaana

AU - Haukka, Jari

AU - Pillas, Demetris

AU - Tzoulaki, Ioanna

AU - Molitor, Jassy

AU - Hoggart, Clive

AU - Coin, Lachlan J. M.

AU - Whittaker, John

AU - Pouta, Anneli

AU - Hartikainen, Anna-Liisa

AU - Freimer, Nelson B.

AU - Widen, Elisabeth

AU - Peltonen, Leena

AU - Elliott, Paul

AU - McCarthy, Mark I.

AU - Jarvelin, Marjo-Riitta

N1 - M1 - 3 Sovio U Bennett AJ Millwood IY Molitor J O'Reilly PF Timpson NJ Kaakinen M Laitinen J Haukka J Pillas D Tzoulaki I Hoggart C Coin LJ Whittaker J Pouta A Hartikainen AL Freimer NB Widen E Peltonen L Elliott P McCarthy MI Jarvelin MR 1RL1MH083268-01 (United States NIMH NIH HHS) 5R01HL087679-02 (United States NHLBI NIH HHS) G0500539 (United Kingdom Medical Research Council) G0600705 (United Kingdom Medical Research Council) GR069224 (United Kingdom Wellcome Trust)

PY - 2009

Y1 - 2009

N2 - Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with adult height (p

AB - Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with adult height (p

U2 - 10.1371/journal.pgen.1000409

DO - 10.1371/journal.pgen.1000409

M3 - Article (Academic Journal)

C2 - 19266077

SN - 1553-7390

VL - 5

SP - e1000409

JO - PLOS Genetics

JF - PLOS Genetics

IS - 3

ER -

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966: PLoS Genetics

Abstract

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