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Genetic evidence for assortative mating on alcohol consumption in the UK Biobank

Research output: Contribution to journalArticle

Original languageEnglish
Article number5039 (2019)
Number of pages10
JournalNature Communications
Volume10
DOIs
DateAccepted/In press - 9 Sep 2019
DatePublished (current) - 19 Nov 2019

Abstract

Alcohol use is correlated within spouse-pairs, but it is difficult to disentangle effects of alcohol consumption on mate-selection from social factors or the shared spousal environment. We hypothesised that genetic variants related to alcohol consumption may, via their effect on alcohol behaviour, influence mate selection. Here, we find strong evidence that an individual’s self-reported alcohol consumption and their genotype at rs1229984, a missense variant in ADH1B, are associated with their partner’s self-reported alcohol use. Applying Mendelian randomization, we estimate that a unit increase in an individual’s weekly alcohol consumption increases partner’s alcohol consumption by 0.26 units (95% C.I. 0.15, 0.38; P=8.20x10-6). Furthermore, we find evidence of spousal genotypic concordance for rs1229984, suggesting that spousal concordance for alcohol consumption existed prior to cohabitation. Although the SNP is strongly associated with ancestry, our results suggest some concordance independent of population stratification. Our findings suggest that alcohol behaviour directly influences mate selection.

    Research areas

  • behavioural genetics, epidemiology, genetics, human behaviour

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Nature Research at https://www.nature.com/articles/s41467-019-12424-x . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

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