Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis

Rachelle Donn, Stuart Ellison, Rebecca Lamb, Thomas Day, Eileen Baildam, Athimalaipet V Ramanan

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA).
Original languageEnglish
Pages (from-to)869-74
Number of pages6
JournalArthritis and Rheumatism
Volume58
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Polymorphism, Single Nucleotide
  • Arthritis, Juvenile Rheumatoid
  • Lymphohistiocytosis, Hemophagocytic
  • Pore Forming Cytotoxic Proteins
  • Humans
  • Macrophage Activation
  • Membrane Proteins
  • Genotype
  • Haplotypes
  • rab GTP-Binding Proteins
  • Risk Factors
  • Case-Control Studies
  • Granzymes
  • Genetic Predisposition to Disease

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