Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis

Rachelle Donn; Stuart Ellison; Rebecca Lamb; Thomas Day; Eileen Baildam; Athimalaipet V Ramanan

doi:10.1002/art.23270

Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis

Rachelle Donn, Stuart Ellison, Rebecca Lamb, Thomas Day, Eileen Baildam, Athimalaipet V Ramanan

Research output: Contribution to journal › Article (Academic Journal) › peer-review

27 Citations (Scopus)

Abstract

To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA).

Original language	English
Pages (from-to)	869-74
Number of pages	6
Journal	Arthritis and Rheumatism
Volume	58
Issue number	3
DOIs	https://doi.org/10.1002/art.23270
Publication status	Published - Mar 2008

Keywords

Polymorphism, Single Nucleotide
Arthritis, Juvenile Rheumatoid
Lymphohistiocytosis, Hemophagocytic
Pore Forming Cytotoxic Proteins
Humans
Macrophage Activation
Membrane Proteins
Genotype
Haplotypes
rab GTP-Binding Proteins
Risk Factors
Case-Control Studies
Granzymes
Genetic Predisposition to Disease

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@article{1c661a1d969546d8a6ff95cbd78c3bc6,

title = "Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis",

abstract = "To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA).",

keywords = "Polymorphism, Single Nucleotide, Arthritis, Juvenile Rheumatoid, Lymphohistiocytosis, Hemophagocytic, Pore Forming Cytotoxic Proteins, Humans, Macrophage Activation, Membrane Proteins, Genotype, Haplotypes, rab GTP-Binding Proteins, Risk Factors, Case-Control Studies, Granzymes, Genetic Predisposition to Disease",

author = "Rachelle Donn and Stuart Ellison and Rebecca Lamb and Thomas Day and Eileen Baildam and Ramanan, \{Athimalaipet V\}",

year = "2008",

month = mar,

doi = "10.1002/art.23270",

language = "English",

volume = "58",

pages = "869--74",

journal = "Arthritis and Rheumatism",

issn = "0004-3591",

publisher = "John Wiley \& Sons, Inc",

number = "3",

}

TY - JOUR

T1 - Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis

AU - Donn, Rachelle

AU - Ellison, Stuart

AU - Lamb, Rebecca

AU - Day, Thomas

AU - Baildam, Eileen

AU - Ramanan, Athimalaipet V

PY - 2008/3

Y1 - 2008/3

N2 - To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA).

AB - To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA).

KW - Polymorphism, Single Nucleotide

KW - Arthritis, Juvenile Rheumatoid

KW - Lymphohistiocytosis, Hemophagocytic

KW - Pore Forming Cytotoxic Proteins

KW - Humans

KW - Macrophage Activation

KW - Membrane Proteins

KW - Genotype

KW - Haplotypes

KW - rab GTP-Binding Proteins

KW - Risk Factors

KW - Case-Control Studies

KW - Granzymes

KW - Genetic Predisposition to Disease

U2 - 10.1002/art.23270

DO - 10.1002/art.23270

M3 - Article (Academic Journal)

C2 - 18311812

SN - 0004-3591

VL - 58

SP - 869

EP - 874

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 3

ER -

Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis

Abstract

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