Genetic loci influencing kidney function and chronic kidney disease

JC Chambers, W Zhang, GM Lord, P van der Harst, al Sehmi JS et, D Lawlor, JS Sehmi, [No Value] Gale D P, [No Value] Wass M N, [No Value] Ahmadi K R, [No Value] Bakker S J L, [No Value] Beckmann J, [No Value] Bilo H J G, Bochud # # Murielle, [No Value] Bochud M, [No Value] Brown M J, [No Value] Caulfield M J, M Connell J, [No Value] Cook H T, [No Value] Cotlarciuc I[No Value] de Silva R, G Deng, O Devuyst, [No Value] Dikkeschei L D, [No Value] Dimkovic N, [No Value] Dockrell M

Research output: Contribution to journalArticle (Academic Journal)peer-review

191 Citations (Scopus)

Abstract

Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Translated title of the contributionGenetic loci influencing kidney function and chronic kidney disease
Original languageEnglish
Pages (from-to)373 - 375
Number of pages2
JournalNature Genetics
Volume42
DOIs
Publication statusPublished - Apr 2010

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