Genetic loci influencing kidney function and chronic kidney disease

JC Chambers; W Zhang; GM Lord; P van der Harst; D Lawlor; JS Sehmi; [No Value] Gale D P; [No Value] Wass M N; [No Value] Ahmadi K R; [No Value] Bakker S J L; [No Value] Beckmann J; [No Value] Bilo H J G; Bochud # # Murielle; [No Value] Bochud M; [No Value] Brown M J; [No Value] Caulfield M J; M Connell J; [No Value] Cook H T; [No Value] Cotlarciuc I; [No Value] de Silva R; G Deng; O Devuyst; [No Value] Dikkeschei L D; [No Value] Dimkovic N; [No Value] Dockrell M

doi:10.1038/ng.566

Genetic loci influencing kidney function and chronic kidney disease

JC Chambers, W Zhang, GM Lord, P van der Harst, D Lawlor, JS Sehmi, [No Value] Gale D P, [No Value] Wass M N, [No Value] Ahmadi K R, [No Value] Bakker S J L, [No Value] Beckmann J, [No Value] Bilo H J G, Bochud # # Murielle, [No Value] Bochud M, [No Value] Brown M J, [No Value] Caulfield M J, M Connell J, [No Value] Cook H T, [No Value] Cotlarciuc I, [No Value] de Silva RG Deng, O Devuyst, [No Value] Dikkeschei L D, [No Value] Dimkovic N, [No Value] Dockrell M

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

243 Citations (Scopus)

Abstract

Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Translated title of the contribution	Genetic loci influencing kidney function and chronic kidney disease
Original language	English
Pages (from-to)	373 - 375
Number of pages	2
Journal	Nature Genetics
Volume	42
DOIs	https://doi.org/10.1038/ng.566
Publication status	Published - Apr 2010

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Chambers, JC., Zhang, W., Lord, GM., van der Harst, P., Lawlor, D., Sehmi, JS., Gale D P, N. V., Wass M N, N. V., Ahmadi K R, N. V., Bakker S J L, N. V., Beckmann J, N. V., Bilo H J G, N. V., # # Murielle, B., Bochud M, N. V., Brown M J, N. V., Caulfield M J, N. V., Connell J, M., Cook H T, N. V., Cotlarciuc I, N. V., ... Dockrell M, N. V. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42, 373 - 375. https://doi.org/10.1038/ng.566

@article{47478663313e49889b693dbebd818887,

title = "Genetic loci influencing kidney function and chronic kidney disease",

abstract = "Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.",

author = "JC Chambers and W Zhang and GM Lord and \{van der Harst\}, P and D Lawlor and JS Sehmi and \{Gale D P\}, \{[No Value]\} and \{Wass M N\}, \{[No Value]\} and \{Ahmadi K R\}, \{[No Value]\} and \{Bakker S J L\}, \{[No Value]\} and \{Beckmann J\}, \{[No Value]\} and \{Bilo H J G\}, \{[No Value]\} and \{\# \# Murielle\}, Bochud and \{Bochud M\}, \{[No Value]\} and \{Brown M J\}, \{[No Value]\} and \{Caulfield M J\}, \{[No Value]\} and \{Connell J\}, M and \{Cook H T\}, \{[No Value]\} and \{Cotlarciuc I\}, \{[No Value]\} and \{de Silva R\}, \{[No Value]\} and G Deng and O Devuyst and \{Dikkeschei L D\}, \{[No Value]\} and \{Dimkovic N\}, \{[No Value]\} and \{Dockrell M\}, \{[No Value]\}",

year = "2010",

month = apr,

doi = "10.1038/ng.566",

language = "English",

volume = "42",

pages = "373 -- 375",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

}

Chambers, JC, Zhang, W, Lord, GM, van der Harst, P, Lawlor, D, Sehmi, JS, Gale D P, NV, Wass M N, NV, Ahmadi K R, NV, Bakker S J L, NV, Beckmann J, NV, Bilo H J G, NV, # # Murielle, B, Bochud M, NV, Brown M J, NV, Caulfield M J, NV, Connell J, M, Cook H T, NV, Cotlarciuc I, NV, de Silva R, NV, Deng, G, Devuyst, O, Dikkeschei L D, NV, Dimkovic N, NV & Dockrell M, NV 2010, 'Genetic loci influencing kidney function and chronic kidney disease', Nature Genetics, vol. 42, pp. 373 - 375. https://doi.org/10.1038/ng.566

TY - JOUR

T1 - Genetic loci influencing kidney function and chronic kidney disease

AU - Chambers, JC

AU - Zhang, W

AU - Lord, GM

AU - van der Harst, P

AU - Lawlor, D

AU - Sehmi, JS

AU - Gale D P, [No Value]

AU - Wass M N, [No Value]

AU - Ahmadi K R, [No Value]

AU - Bakker S J L, [No Value]

AU - Beckmann J, [No Value]

AU - Bilo H J G, [No Value]

AU - # # Murielle, Bochud

AU - Bochud M, [No Value]

AU - Brown M J, [No Value]

AU - Caulfield M J, [No Value]

AU - Connell J, M

AU - Cook H T, [No Value]

AU - Cotlarciuc I, [No Value]

AU - de Silva R, [No Value]

AU - Deng, G

AU - Devuyst, O

AU - Dikkeschei L D, [No Value]

AU - Dimkovic N, [No Value]

AU - Dockrell M, [No Value]

PY - 2010/4

Y1 - 2010/4

N2 - Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

AB - Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

U2 - 10.1038/ng.566

DO - 10.1038/ng.566

M3 - Article (Academic Journal)

C2 - 20383145

SN - 1061-4036

VL - 42

SP - 373

EP - 375

JO - Nature Genetics

JF - Nature Genetics

ER -

Genetic loci influencing kidney function and chronic kidney disease

Abstract

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