Genetic markers as instrumental variables

Stephanie Von Hinke Kessler Scholder; George Davey Smith; Debbie A Lawlor; Carol Propper; Frank Windmeijer

doi:10.1016/j.jhealeco.2015.10.007

Genetic markers as instrumental variables

Stephanie Von Hinke Kessler Scholder, George Davey Smith, Debbie A Lawlor, Carol Propper, Frank Windmeijer

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Abstract

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications.

Original language	English
Pages (from-to)	131-148
Number of pages	18
Journal	Journal of Health Economics
Volume	45
Early online date	10 Nov 2015
DOIs	https://doi.org/10.1016/j.jhealeco.2015.10.007
Publication status	Published - Jan 2016

Keywords

ALSPAC
Genetic Variants
Instrumental Variables
Mendelian Randomization
Potential Outcomes

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10.1016/j.jhealeco.2015.10.007

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© 2015 The Authors. Published by Elsevier B.V.
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IEU Theme 3
Windmeijer, F. (Principal Investigator), Tilling, K. M. (Researcher) & Tilling, K. M. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - Programme 5
Lawlor, D. A. (Principal Investigator) & Lawlor, D. A. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

Professor Stephanie von Hinke
- s.vonhinkebristol.acuk
- School of Economics - Professor of Economics
- Bristol Poverty Institute
- Bristol Population Health Science Institute
- Centre for Market and Public Organisation
Person: Academic , Member

Cite this

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title = "Genetic markers as instrumental variables",

abstract = "The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications.",

keywords = "ALSPAC, Genetic Variants, Instrumental Variables, Mendelian Randomization, Potential Outcomes",

author = "{Von Hinke Kessler Scholder}, Stephanie and {Davey Smith}, George and Lawlor, {Debbie A} and Carol Propper and Frank Windmeijer",

year = "2016",

month = jan,

doi = "10.1016/j.jhealeco.2015.10.007",

language = "English",

volume = "45",

pages = "131--148",

journal = "Journal of Health Economics",

issn = "0167-6296",

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AU - Von Hinke Kessler Scholder, Stephanie

AU - Davey Smith, George

AU - Lawlor, Debbie A

AU - Propper, Carol

AU - Windmeijer, Frank

PY - 2016/1

Y1 - 2016/1

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AB - The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications.

KW - ALSPAC

KW - Genetic Variants

KW - Instrumental Variables

KW - Mendelian Randomization

KW - Potential Outcomes

U2 - 10.1016/j.jhealeco.2015.10.007

DO - 10.1016/j.jhealeco.2015.10.007

M3 - Article (Academic Journal)

C2 - 26614692

SN - 0167-6296

VL - 45

SP - 131

EP - 148

JO - Journal of Health Economics

JF - Journal of Health Economics

ER -

Genetic markers as instrumental variables

Abstract

Keywords

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Projects

IEU Theme 3

MRC UoB UNITE Unit - Programme 5

MRC UoB UNITE Unit - Programme 1

Profiles

Professor Stephanie von Hinke

Cite this