Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme

Tamuno K Alfred; Yoav Ben-Shlomo; Rachel Cooper; Rebecca Hardy; Cyrus Cooper; Ian J. Deary; David Gunnell; Sarah E. Harris; Meena Kumari; Richard M. Martin; Avan Aihie Sayer; John M. Starr; Diana Kuh; Ian N. M. Day; the HALCyon Study Team

doi:10.1016/j.bone.2012.10.004

Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme

Tamuno K Alfred, Yoav Ben-Shlomo, Rachel Cooper, Rebecca Hardy, Cyrus Cooper, Ian J. Deary, David Gunnell, Sarah E. Harris, Meena Kumari, Richard M. Martin, Avan Aihie Sayer, John M. Starr, Diana Kuh, Ian N. M. Day, the HALCyon Study Team

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Abstract

Background: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability.

Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90 + years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759. RANKL) and one associated with osteoarthritis risk rs3815148 (COGS). Meta-analysis was used to pool within-study effects of the associations between each of the polymorphisms and measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance.

Results: Few important associations were observed among the several tests. We found that carriers of the serum calcium-raising allele had poorer grip strength compared with non-carriers (pooled p = 0.05, n = 11,239) after adjusting for age and sex. Inconsistent results were observed for the two variants associated with BMD and we found no evidence for an association between rs3815148 (COGS) and any of the physical capability measures.

Conclusion: Our findings suggest elevated serum calcium levels may lead to lower grip strength, though this requires further replication. Our results do not provide evidence for a substantial influence of these variants in ESR1, RANKL and COG5 on physical capability in older adults. (C) 2012 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	278-285
Number of pages	8
Journal	Bone
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/j.bone.2012.10.004
Publication status	Published - Jan 2013

Keywords

Calcium
Osteoarthritis
Grip strength
Aging
HERTFORDSHIRE COHORT
CALCIUM INTAKE
VERTEBRAL FRACTURE
SENSING-RECEPTOR GENE
COHORT PROFILE
MINERAL DENSITY
Bone mineral density
25-HYDROXYVITAMIN D
MUSCLE STRENGTH
GRIP STRENGTH
POSTMENOPAUSAL WOMEN

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Alfred, T. K., Ben-Shlomo, Y., Cooper, R., Hardy, R., Cooper, C., Deary, I. J., Gunnell, D., Harris, S. E., Kumari, M., Martin, R. M., Sayer, A. A., Starr, J. M., Kuh, D., Day, I. N. M., & the HALCyon Study Team (2013). Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme. Bone, 52(1), 278-285. https://doi.org/10.1016/j.bone.2012.10.004

@article{5bc4481295124817ba06470e4ce078c0,

title = "Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme",

abstract = "Background: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability.Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90 + years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759. RANKL) and one associated with osteoarthritis risk rs3815148 (COGS). Meta-analysis was used to pool within-study effects of the associations between each of the polymorphisms and measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance.Results: Few important associations were observed among the several tests. We found that carriers of the serum calcium-raising allele had poorer grip strength compared with non-carriers (pooled p = 0.05, n = 11,239) after adjusting for age and sex. Inconsistent results were observed for the two variants associated with BMD and we found no evidence for an association between rs3815148 (COGS) and any of the physical capability measures.Conclusion: Our findings suggest elevated serum calcium levels may lead to lower grip strength, though this requires further replication. Our results do not provide evidence for a substantial influence of these variants in ESR1, RANKL and COG5 on physical capability in older adults. (C) 2012 Elsevier Inc. All rights reserved.",

keywords = "Calcium, Osteoarthritis, Grip strength, Aging, HERTFORDSHIRE COHORT, CALCIUM INTAKE, VERTEBRAL FRACTURE, SENSING-RECEPTOR GENE, COHORT PROFILE, MINERAL DENSITY, Bone mineral density, 25-HYDROXYVITAMIN D, MUSCLE STRENGTH, GRIP STRENGTH, POSTMENOPAUSAL WOMEN",

author = "Alfred, {Tamuno K} and Yoav Ben-Shlomo and Rachel Cooper and Rebecca Hardy and Cyrus Cooper and Deary, {Ian J.} and David Gunnell and Harris, {Sarah E.} and Meena Kumari and Martin, {Richard M.} and Sayer, {Avan Aihie} and Starr, {John M.} and Diana Kuh and Day, {Ian N. M.} and {the HALCyon Study Team}",

year = "2013",

month = jan,

doi = "10.1016/j.bone.2012.10.004",

language = "English",

volume = "52",

pages = "278--285",

journal = "Bone",

issn = "1873-2763",

publisher = "Pergamon Press",

number = "1",

}

Alfred, TK, Ben-Shlomo, Y, Cooper, R, Hardy, R, Cooper, C, Deary, IJ, Gunnell, D, Harris, SE, Kumari, M, Martin, RM, Sayer, AA, Starr, JM, Kuh, D, Day, INM & the HALCyon Study Team 2013, 'Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme', Bone, vol. 52, no. 1, pp. 278-285. https://doi.org/10.1016/j.bone.2012.10.004

TY - JOUR

T1 - Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme

AU - Alfred, Tamuno K

AU - Ben-Shlomo, Yoav

AU - Cooper, Rachel

AU - Hardy, Rebecca

AU - Cooper, Cyrus

AU - Deary, Ian J.

AU - Gunnell, David

AU - Harris, Sarah E.

AU - Kumari, Meena

AU - Martin, Richard M.

AU - Sayer, Avan Aihie

AU - Starr, John M.

AU - Kuh, Diana

AU - Day, Ian N. M.

AU - the HALCyon Study Team

PY - 2013/1

Y1 - 2013/1

N2 - Background: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability.Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90 + years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759. RANKL) and one associated with osteoarthritis risk rs3815148 (COGS). Meta-analysis was used to pool within-study effects of the associations between each of the polymorphisms and measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance.Results: Few important associations were observed among the several tests. We found that carriers of the serum calcium-raising allele had poorer grip strength compared with non-carriers (pooled p = 0.05, n = 11,239) after adjusting for age and sex. Inconsistent results were observed for the two variants associated with BMD and we found no evidence for an association between rs3815148 (COGS) and any of the physical capability measures.Conclusion: Our findings suggest elevated serum calcium levels may lead to lower grip strength, though this requires further replication. Our results do not provide evidence for a substantial influence of these variants in ESR1, RANKL and COG5 on physical capability in older adults. (C) 2012 Elsevier Inc. All rights reserved.

AB - Background: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability.Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90 + years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759. RANKL) and one associated with osteoarthritis risk rs3815148 (COGS). Meta-analysis was used to pool within-study effects of the associations between each of the polymorphisms and measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance.Results: Few important associations were observed among the several tests. We found that carriers of the serum calcium-raising allele had poorer grip strength compared with non-carriers (pooled p = 0.05, n = 11,239) after adjusting for age and sex. Inconsistent results were observed for the two variants associated with BMD and we found no evidence for an association between rs3815148 (COGS) and any of the physical capability measures.Conclusion: Our findings suggest elevated serum calcium levels may lead to lower grip strength, though this requires further replication. Our results do not provide evidence for a substantial influence of these variants in ESR1, RANKL and COG5 on physical capability in older adults. (C) 2012 Elsevier Inc. All rights reserved.

KW - Calcium

KW - Osteoarthritis

KW - Grip strength

KW - Aging

KW - HERTFORDSHIRE COHORT

KW - CALCIUM INTAKE

KW - VERTEBRAL FRACTURE

KW - SENSING-RECEPTOR GENE

KW - COHORT PROFILE

KW - MINERAL DENSITY

KW - Bone mineral density

KW - 25-HYDROXYVITAMIN D

KW - MUSCLE STRENGTH

KW - GRIP STRENGTH

KW - POSTMENOPAUSAL WOMEN

U2 - 10.1016/j.bone.2012.10.004

DO - 10.1016/j.bone.2012.10.004

M3 - Article (Academic Journal)

C2 - 23072920

SN - 1873-2763

VL - 52

SP - 278

EP - 285

JO - Bone

JF - Bone

IS - 1

ER -

Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme

Abstract

Keywords

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