Genetic predictors of fibrin D-dimer levels in healthy adults

Nicholas L Smith, Jennifer E Huffman, David P Strachan, Jie Huang, Abbas Dehghan, Stella Trompet, Lorna M Lopez, So-Youn Shin, Jens Baumert, Veronique Vitart, Joshua C Bis, Sarah H Wild, Ann Rumley, Qiong Yang, Andre G Uitterlinden, David J Stott, Gail Davies, Angela M Carter, Barbara Thorand, Ozren PolašekBarbara McKnight, Harry Campbell, Alicja R Rudnicka, Ming-Huei Chen, Brendan M Buckley, Sarah E Harris, Annette Peters, Drazen Pulanic, Thomas Lumley, Anton J M de Craen, David C Liewald, Christian Gieger, Susan Campbell, Ian Ford, Alan J Gow, Michelle Luciano, David J Porteous, Xiuqing Guo, Naveed Sattar, Albert Tenesa, Mary Cushman, P Eline Slagboom, Peter M Visscher, Tim D Spector, Thomas Illig, Igor Rudan, Edwin G Bovill, Alan F Wright, Wendy L McArdle, Geoffrey Tofler, Albert Hofman, Rudi G J Westendorp, John M Starr, Peter J Grant, Mahir Karakas, Nicholas D Hastie, Bruce M Psaty, James F Wilson, Gordon D O Lowe, Christopher J O'Donnell, Jacqueline C M Witteman, J Wouter Jukema, Ian J Deary, Nicole Soranzo, Wolfgang Koenig, Caroline Hayward

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Abstract

Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.
Original languageEnglish
Pages (from-to)1864-72
Number of pages9
JournalCirculation
Volume123
Issue number17
DOIs
Publication statusPublished - 2011

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Smith, N. L., Huffman, J. E., Strachan, D. P., Huang, J., Dehghan, A., Trompet, S., Lopez, L. M., Shin, S-Y., Baumert, J., Vitart, V., Bis, J. C., Wild, S. H., Rumley, A., Yang, Q., Uitterlinden, A. G., Stott, D. J., Davies, G., Carter, A. M., Thorand, B., ... Hayward, C. (2011). Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation, 123(17), 1864-72. https://doi.org/10.1161/CIRCULATIONAHA.110.009480