Genetic predictors of fibrin D-dimer levels in healthy adults

Nicholas L Smith, Jennifer E Huffman, David P Strachan, Jie Huang, Abbas Dehghan, Stella Trompet, Lorna M Lopez, So-Youn Shin, Jens Baumert, Veronique Vitart, Joshua C Bis, Sarah H Wild, Ann Rumley, Qiong Yang, Andre G Uitterlinden, David J Stott, Gail Davies, Angela M Carter, Barbara Thorand, Ozren PolašekBarbara McKnight, Harry Campbell, Alicja R Rudnicka, Ming-Huei Chen, Brendan M Buckley, Sarah E Harris, Annette Peters, Drazen Pulanic, Thomas Lumley, Anton J M de Craen, David C Liewald, Christian Gieger, Susan Campbell, Ian Ford, Alan J Gow, Michelle Luciano, David J Porteous, Xiuqing Guo, Naveed Sattar, Albert Tenesa, Mary Cushman, P Eline Slagboom, Peter M Visscher, Tim D Spector, Thomas Illig, Igor Rudan, Edwin G Bovill, Alan F Wright, Wendy L McArdle, Geoffrey Tofler, Albert Hofman, Rudi G J Westendorp, John M Starr, Peter J Grant, Mahir Karakas, Nicholas D Hastie, Bruce M Psaty, James F Wilson, Gordon D O Lowe, Christopher J O'Donnell, Jacqueline C M Witteman, J Wouter Jukema, Ian J Deary, Nicole Soranzo, Wolfgang Koenig, Caroline Hayward

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Citations (Scopus)

Abstract

Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.
Original languageEnglish
Pages (from-to)1864-72
Number of pages9
JournalCirculation
Volume123
Issue number17
DOIs
Publication statusPublished - 2011

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