Genetic predictors of fibrin D-dimer levels in healthy adults

Nicholas L Smith; Jennifer E Huffman; David P Strachan; Jie Huang; Abbas Dehghan; Stella Trompet; Lorna M Lopez; So-Youn Shin; Jens Baumert; Veronique Vitart; Joshua C Bis; Sarah H Wild; Ann Rumley; Qiong Yang; Andre G Uitterlinden; David J Stott; Gail Davies; Angela M Carter; Barbara Thorand; Ozren Polašek; Barbara McKnight; Harry Campbell; Alicja R Rudnicka; Ming-Huei Chen; Brendan M Buckley; Sarah E Harris; Annette Peters; Drazen Pulanic; Thomas Lumley; Anton J M de Craen; David C Liewald; Christian Gieger; Susan Campbell; Ian Ford; Alan J Gow; Michelle Luciano; David J Porteous; Xiuqing Guo; Naveed Sattar; Albert Tenesa; Mary Cushman; P Eline Slagboom; Peter M Visscher; Tim D Spector; Thomas Illig; Igor Rudan; Edwin G Bovill; Alan F Wright; Wendy L McArdle; Geoffrey Tofler; Albert Hofman; Rudi G J Westendorp; John M Starr; Peter J Grant; Mahir Karakas; Nicholas D Hastie; Bruce M Psaty; James F Wilson; Gordon D O Lowe; Christopher J O'Donnell; Jacqueline C M Witteman; J Wouter Jukema; Ian J Deary; Nicole Soranzo; Wolfgang Koenig; Caroline Hayward

doi:10.1161/CIRCULATIONAHA.110.009480

Genetic predictors of fibrin D-dimer levels in healthy adults

Nicholas L Smith
, Jennifer E Huffman
, David P Strachan
, Jie Huang
, Abbas Dehghan
, Stella Trompet
, Lorna M Lopez
, So-Youn Shin
, Jens Baumert
, Veronique Vitart
, Joshua C Bis
, Sarah H Wild
, Ann Rumley
, Qiong Yang
, Andre G Uitterlinden
, David J Stott
, Gail Davies
, Angela M Carter
, Barbara Thorand
, Ozren Polašek

Barbara McKnight, Harry Campbell, Alicja R Rudnicka, Ming-Huei Chen, Brendan M Buckley, Sarah E Harris, Annette Peters, Drazen Pulanic, Thomas Lumley, Anton J M de Craen, David C Liewald, Christian Gieger, Susan Campbell, Ian Ford, Alan J Gow, Michelle Luciano, David J Porteous, Xiuqing Guo, Naveed Sattar, Albert Tenesa, Mary Cushman, P Eline Slagboom, Peter M Visscher, Tim D Spector, Thomas Illig, Igor Rudan, Edwin G Bovill, Alan F Wright, Wendy L McArdle, Geoffrey Tofler, Albert Hofman, Rudi G J Westendorp, John M Starr, Peter J Grant, Mahir Karakas, Nicholas D Hastie, Bruce M Psaty, James F Wilson, Gordon D O Lowe, Christopher J O'Donnell, Jacqueline C M Witteman, J Wouter Jukema, Ian J Deary, Nicole Soranzo, Wolfgang Koenig, Caroline Hayward

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

58 Citations (Scopus)

Abstract

Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.

Original language	English
Pages (from-to)	1864-72
Number of pages	9
Journal	Circulation
Volume	123
Issue number	17
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.009480
Publication status	Published - 2011

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Smith, N. L., Huffman, J. E., Strachan, D. P., Huang, J., Dehghan, A., Trompet, S., Lopez, L. M., Shin, S.-Y., Baumert, J., Vitart, V., Bis, J. C., Wild, S. H., Rumley, A., Yang, Q., Uitterlinden, A. G., Stott, D. J., Davies, G., Carter, A. M., Thorand, B., ... Hayward, C. (2011). Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation, 123(17), 1864-72. https://doi.org/10.1161/CIRCULATIONAHA.110.009480

@article{d5b01aab3bce4e62bcafef8a73de6992,

title = "Genetic predictors of fibrin D-dimer levels in healthy adults",

abstract = "Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.",

author = "Smith, \{Nicholas L\} and Huffman, \{Jennifer E\} and Strachan, \{David P\} and Jie Huang and Abbas Dehghan and Stella Trompet and Lopez, \{Lorna M\} and So-Youn Shin and Jens Baumert and Veronique Vitart and Bis, \{Joshua C\} and Wild, \{Sarah H\} and Ann Rumley and Qiong Yang and Uitterlinden, \{Andre G\} and Stott, \{David J\} and Gail Davies and Carter, \{Angela M\} and Barbara Thorand and Ozren Pola{\v s}ek and Barbara McKnight and Harry Campbell and Rudnicka, \{Alicja R\} and Ming-Huei Chen and Buckley, \{Brendan M\} and Harris, \{Sarah E\} and Annette Peters and Drazen Pulanic and Thomas Lumley and \{de Craen\}, \{Anton J M\} and Liewald, \{David C\} and Christian Gieger and Susan Campbell and Ian Ford and Gow, \{Alan J\} and Michelle Luciano and Porteous, \{David J\} and Xiuqing Guo and Naveed Sattar and Albert Tenesa and Mary Cushman and Slagboom, \{P Eline\} and Visscher, \{Peter M\} and Spector, \{Tim D\} and Thomas Illig and Igor Rudan and Bovill, \{Edwin G\} and Wright, \{Alan F\} and McArdle, \{Wendy L\} and Geoffrey Tofler and Albert Hofman and Westendorp, \{Rudi G J\} and Starr, \{John M\} and Grant, \{Peter J\} and Mahir Karakas and Hastie, \{Nicholas D\} and Psaty, \{Bruce M\} and Wilson, \{James F\} and Lowe, \{Gordon D O\} and O'Donnell, \{Christopher J\} and Witteman, \{Jacqueline C M\} and Jukema, \{J Wouter\} and Deary, \{Ian J\} and Nicole Soranzo and Wolfgang Koenig and Caroline Hayward",

year = "2011",

doi = "10.1161/CIRCULATIONAHA.110.009480",

language = "English",

volume = "123",

pages = "1864--72",

journal = "Circulation",

issn = "1524-4539",

publisher = "Lippincott Williams and Wilkins",

number = "17",

}

Smith, NL, Huffman, JE, Strachan, DP, Huang, J, Dehghan, A, Trompet, S, Lopez, LM, Shin, S-Y, Baumert, J, Vitart, V, Bis, JC, Wild, SH, Rumley, A, Yang, Q, Uitterlinden, AG, Stott, DJ, Davies, G, Carter, AM, Thorand, B, Polašek, O, McKnight, B, Campbell, H, Rudnicka, AR, Chen, M-H, Buckley, BM, Harris, SE, Peters, A, Pulanic, D, Lumley, T, de Craen, AJM, Liewald, DC, Gieger, C, Campbell, S, Ford, I, Gow, AJ, Luciano, M, Porteous, DJ, Guo, X, Sattar, N, Tenesa, A, Cushman, M, Slagboom, PE, Visscher, PM, Spector, TD, Illig, T, Rudan, I, Bovill, EG, Wright, AF, McArdle, WL, Tofler, G, Hofman, A, Westendorp, RGJ, Starr, JM, Grant, PJ, Karakas, M, Hastie, ND, Psaty, BM, Wilson, JF, Lowe, GDO, O'Donnell, CJ, Witteman, JCM, Jukema, JW, Deary, IJ, Soranzo, N, Koenig, W & Hayward, C 2011, 'Genetic predictors of fibrin D-dimer levels in healthy adults', Circulation, vol. 123, no. 17, pp. 1864-72. https://doi.org/10.1161/CIRCULATIONAHA.110.009480

TY - JOUR

T1 - Genetic predictors of fibrin D-dimer levels in healthy adults

AU - Smith, Nicholas L

AU - Huffman, Jennifer E

AU - Strachan, David P

AU - Huang, Jie

AU - Dehghan, Abbas

AU - Trompet, Stella

AU - Lopez, Lorna M

AU - Shin, So-Youn

AU - Baumert, Jens

AU - Vitart, Veronique

AU - Bis, Joshua C

AU - Wild, Sarah H

AU - Rumley, Ann

AU - Yang, Qiong

AU - Uitterlinden, Andre G

AU - Stott, David J

AU - Davies, Gail

AU - Carter, Angela M

AU - Thorand, Barbara

AU - Polašek, Ozren

AU - McKnight, Barbara

AU - Campbell, Harry

AU - Rudnicka, Alicja R

AU - Chen, Ming-Huei

AU - Buckley, Brendan M

AU - Harris, Sarah E

AU - Peters, Annette

AU - Pulanic, Drazen

AU - Lumley, Thomas

AU - de Craen, Anton J M

AU - Liewald, David C

AU - Gieger, Christian

AU - Campbell, Susan

AU - Ford, Ian

AU - Gow, Alan J

AU - Luciano, Michelle

AU - Porteous, David J

AU - Guo, Xiuqing

AU - Sattar, Naveed

AU - Tenesa, Albert

AU - Cushman, Mary

AU - Slagboom, P Eline

AU - Visscher, Peter M

AU - Spector, Tim D

AU - Illig, Thomas

AU - Rudan, Igor

AU - Bovill, Edwin G

AU - Wright, Alan F

AU - McArdle, Wendy L

AU - Tofler, Geoffrey

AU - Hofman, Albert

AU - Westendorp, Rudi G J

AU - Starr, John M

AU - Grant, Peter J

AU - Karakas, Mahir

AU - Hastie, Nicholas D

AU - Psaty, Bruce M

AU - Wilson, James F

AU - Lowe, Gordon D O

AU - O'Donnell, Christopher J

AU - Witteman, Jacqueline C M

AU - Jukema, J Wouter

AU - Deary, Ian J

AU - Soranzo, Nicole

AU - Koenig, Wolfgang

AU - Hayward, Caroline

PY - 2011

Y1 - 2011

N2 - Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.

AB - Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.

U2 - 10.1161/CIRCULATIONAHA.110.009480

DO - 10.1161/CIRCULATIONAHA.110.009480

M3 - Article (Academic Journal)

C2 - 21502573

SN - 1524-4539

VL - 123

SP - 1864

EP - 1872

JO - Circulation

JF - Circulation

IS - 17

ER -

Genetic predictors of fibrin D-dimer levels in healthy adults

Abstract

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