Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

Petroula Proitsi; Michelle Katharine Lupton; Latha Velayudhan; Stephen J. Newhouse; Isabella Fogh; Magda N. Tsolaki; Makrina Daniilidou; Megan Pritchard; Iwona Kłoszewska; Hilkka S. Soininen; Patrizia Mecocci; Bruno J. Vellas; Julie I. Williams; Denise H. Harold; Rebecca J A Sims; Amy Gerrish; Jade A. Chapman; Valentina Escott-Price; Richard J. Abraham; Paul Hollingworth; Marian L. Hamshere; Jaspreet Singh Pahwa; Kimberley Dowzell; Amy J. Williams; Nicola Jones; Charlene Thomas; Alexandra Stretton; Angharad R. Morgan; Katherine Ellie M Williams; Simon Lovestone; John F F Powell; Petroula Proitsi; Michelle K. Lupton; Carol E G Brayne; David C. Rubinsztein; Michael Gill; Brian A. Lawlor; Aoibhinn Lynch; Kevin N. Morgan; Kristelle S. Brown; Peter A. Passmore; David A. Craig; Bernadette M. McGuinness; Janet A. Johnston; Stephen A. Todd; Clive Holmes; David Mann; Ann David Smith; Seth Love; Patrick Gavin Avin Kehoe; John Anthony Hardy; Rita João Guerreiro; Andrew B. Singleton; S. Mead; Nick C. Fox; Martin N. Rossor; John C. Collinge; Wolfgang A. Maier; Frank Jessen; Reinhard Heun; Britta Schürmann; Alfredo L. Ramírez; Tim Becker; Christine Herold; André Lacour; Dmitriy Drichel; Hendrik Van Den Bussche; Isabella Heuser; Johannes Kornhuber; Jens G. Wiltfang; Martin Dichgans; Lutz Frölich; Harald Hampel; Michael H. Hüll; Dan A N Rujescu; Alison M. Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John Clay K Morris; Kevin Mayo; Gill A. Livingston; Nicholas James Bass; Hugh Malcolm Douglas Gurling; Andrew McQuillin; Rhian G. Gwilliam; Panos Deloukas; Markus M. Nöthen; Peter A. Holmans; M. C. O'Donovan; Michael John Owen; Julie O. Williams; Robert Stewart; Pak Chung Sham; Simon Lovestone; John F. Powell

doi:10.1371/journal.pmed.1001713

Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

Petroula Proitsi, Michelle Katharine Lupton, Latha Velayudhan, Stephen J. Newhouse, Isabella Fogh, Magda N. Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kłoszewska, Hilkka S. Soininen, Patrizia Mecocci, Bruno J. Vellas, Julie I. Williams, Denise H. Harold, Rebecca J A Sims, Amy Gerrish, Jade A. Chapman, Valentina Escott-Price, Richard J. Abraham, Paul HollingworthMarian L. Hamshere, Jaspreet Singh Pahwa, Kimberley Dowzell, Amy J. Williams, Nicola Jones, Charlene Thomas, Alexandra Stretton, Angharad R. Morgan, Katherine Ellie M Williams, Simon Lovestone, John F F Powell, Petroula Proitsi, Michelle K. Lupton, Carol E G Brayne, David C. Rubinsztein, Michael Gill, Brian A. Lawlor, Aoibhinn Lynch, Kevin N. Morgan, Kristelle S. Brown, Peter A. Passmore, David A. Craig, Bernadette M. McGuinness, Janet A. Johnston, Stephen A. Todd, Clive Holmes, David Mann, Ann David Smith, Seth Love, Patrick Gavin Avin Kehoe, John Anthony Hardy, Rita João Guerreiro, Andrew B. Singleton, S. Mead, Nick C. Fox, Martin N. Rossor, John C. Collinge, Wolfgang A. Maier, Frank Jessen, Reinhard Heun, Britta Schürmann, Alfredo L. Ramírez, Tim Becker, Christine Herold, André Lacour, Dmitriy Drichel, Hendrik Van Den Bussche, Isabella Heuser, Johannes Kornhuber, Jens G. Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael H. Hüll, Dan A N Rujescu, Alison M. Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John Clay K Morris, Kevin Mayo, Gill A. Livingston, Nicholas James Bass, Hugh Malcolm Douglas Gurling, Andrew McQuillin, Rhian G. Gwilliam, Panos Deloukas, Markus M. Nöthen, Peter A. Holmans, M. C. O'Donovan, Michael John Owen, Julie O. Williams, Robert Stewart, Pak Chung Sham, Simon Lovestone, John F. Powell

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

Original language	English
Journal	PLoS Medicine
Volume	11
Issue number	9
DOIs	https://doi.org/10.1371/journal.pmed.1001713
Publication status	Published - 1 Jan 2014

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10.1371/journal.pmed.1001713

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Proitsi, P., Lupton, M. K., Velayudhan, L., Newhouse, S. J., Fogh, I., Tsolaki, M. N., Daniilidou, M., Pritchard, M., Kłoszewska, I., Soininen, H. S., Mecocci, P., Vellas, B. J., Williams, J. I., Harold, D. H., Sims, R. J. A., Gerrish, A., Chapman, J. A., Escott-Price, V., Abraham, R. J., ... Powell, J. F. (2014). Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis. PLoS Medicine, 11(9). https://doi.org/10.1371/journal.pmed.1001713

Proitsi, Petroula ; Lupton, Michelle Katharine ; Velayudhan, Latha ; Newhouse, Stephen J. ; Fogh, Isabella ; Tsolaki, Magda N. ; Daniilidou, Makrina ; Pritchard, Megan ; Kłoszewska, Iwona ; Soininen, Hilkka S. ; Mecocci, Patrizia ; Vellas, Bruno J. ; Williams, Julie I. ; Harold, Denise H. ; Sims, Rebecca J A ; Gerrish, Amy ; Chapman, Jade A. ; Escott-Price, Valentina ; Abraham, Richard J. ; Hollingworth, Paul ; Hamshere, Marian L. ; Singh Pahwa, Jaspreet ; Dowzell, Kimberley ; Williams, Amy J. ; Jones, Nicola ; Thomas, Charlene ; Stretton, Alexandra ; Morgan, Angharad R. ; Williams, Katherine Ellie M ; Lovestone, Simon ; Powell, John F F ; Proitsi, Petroula ; Lupton, Michelle K. ; Brayne, Carol E G ; Rubinsztein, David C. ; Gill, Michael ; Lawlor, Brian A. ; Lynch, Aoibhinn ; Morgan, Kevin N. ; Brown, Kristelle S. ; Passmore, Peter A. ; Craig, David A. ; McGuinness, Bernadette M. ; Johnston, Janet A. ; Todd, Stephen A. ; Holmes, Clive ; Mann, David ; Smith, Ann David ; Love, Seth ; Kehoe, Patrick Gavin Avin ; Hardy, John Anthony ; Guerreiro, Rita João ; Singleton, Andrew B. ; Mead, S. ; Fox, Nick C. ; Rossor, Martin N. ; Collinge, John C. ; Maier, Wolfgang A. ; Jessen, Frank ; Heun, Reinhard ; Schürmann, Britta ; Ramírez, Alfredo L. ; Becker, Tim ; Herold, Christine ; Lacour, André ; Drichel, Dmitriy ; Van Den Bussche, Hendrik ; Heuser, Isabella ; Kornhuber, Johannes ; Wiltfang, Jens G. ; Dichgans, Martin ; Frölich, Lutz ; Hampel, Harald ; Hüll, Michael H. ; Rujescu, Dan A N ; Goate, Alison M. ; Kauwe, John S K ; Cruchaga, Carlos ; Nowotny, Petra ; Morris, John Clay K ; Mayo, Kevin ; Livingston, Gill A. ; Bass, Nicholas James ; Gurling, Hugh Malcolm Douglas ; McQuillin, Andrew ; Gwilliam, Rhian G. ; Deloukas, Panos ; Nöthen, Markus M. ; Holmans, Peter A. ; O'Donovan, M. C. ; Owen, Michael John ; Williams, Julie O. ; Stewart, Robert ; Sham, Pak Chung ; Lovestone, Simon ; Powell, John F. / Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis. In: PLoS Medicine. 2014 ; Vol. 11, No. 9.

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title = "Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis",

author = "Petroula Proitsi and Lupton, {Michelle Katharine} and Latha Velayudhan and Newhouse, {Stephen J.} and Isabella Fogh and Tsolaki, {Magda N.} and Makrina Daniilidou and Megan Pritchard and Iwona K{\l}oszewska and Soininen, {Hilkka S.} and Patrizia Mecocci and Vellas, {Bruno J.} and Williams, {Julie I.} and Harold, {Denise H.} and Sims, {Rebecca J A} and Amy Gerrish and Chapman, {Jade A.} and Valentina Escott-Price and Abraham, {Richard J.} and Paul Hollingworth and Hamshere, {Marian L.} and {Singh Pahwa}, Jaspreet and Kimberley Dowzell and Williams, {Amy J.} and Nicola Jones and Charlene Thomas and Alexandra Stretton and Morgan, {Angharad R.} and Williams, {Katherine Ellie M} and Simon Lovestone and Powell, {John F F} and Petroula Proitsi and Lupton, {Michelle K.} and Brayne, {Carol E G} and Rubinsztein, {David C.} and Michael Gill and Lawlor, {Brian A.} and Aoibhinn Lynch and Morgan, {Kevin N.} and Brown, {Kristelle S.} and Passmore, {Peter A.} and Craig, {David A.} and McGuinness, {Bernadette M.} and Johnston, {Janet A.} and Todd, {Stephen A.} and Clive Holmes and David Mann and Smith, {Ann David} and Seth Love and Kehoe, {Patrick Gavin Avin} and Hardy, {John Anthony} and Guerreiro, {Rita Jo{\~a}o} and Singleton, {Andrew B.} and S. Mead and Fox, {Nick C.} and Rossor, {Martin N.} and Collinge, {John C.} and Maier, {Wolfgang A.} and Frank Jessen and Reinhard Heun and Britta Sch{\"u}rmann and Ram{\'i}rez, {Alfredo L.} and Tim Becker and Christine Herold and Andr{\'e} Lacour and Dmitriy Drichel and {Van Den Bussche}, Hendrik and Isabella Heuser and Johannes Kornhuber and Wiltfang, {Jens G.} and Martin Dichgans and Lutz Fr{\"o}lich and Harald Hampel and H{\"u}ll, {Michael H.} and Rujescu, {Dan A N} and Goate, {Alison M.} and Kauwe, {John S K} and Carlos Cruchaga and Petra Nowotny and Morris, {John Clay K} and Kevin Mayo and Livingston, {Gill A.} and Bass, {Nicholas James} and Gurling, {Hugh Malcolm Douglas} and Andrew McQuillin and Gwilliam, {Rhian G.} and Panos Deloukas and N{\"o}then, {Markus M.} and Holmans, {Peter A.} and O'Donovan, {M. C.} and Owen, {Michael John} and Williams, {Julie O.} and Robert Stewart and Sham, {Pak Chung} and Simon Lovestone and Powell, {John F.}",

year = "2014",

month = jan,

day = "1",

doi = "10.1371/journal.pmed.1001713",

language = "English",

volume = "11",

journal = "PLoS Medicine",

issn = "1549-1277",

publisher = "Public Library of Science",

number = "9",

}

Proitsi, P, Lupton, MK, Velayudhan, L, Newhouse, SJ, Fogh, I, Tsolaki, MN, Daniilidou, M, Pritchard, M, Kłoszewska, I, Soininen, HS, Mecocci, P, Vellas, BJ, Williams, JI, Harold, DH, Sims, RJA, Gerrish, A, Chapman, JA, Escott-Price, V, Abraham, RJ, Hollingworth, P, Hamshere, ML, Singh Pahwa, J, Dowzell, K, Williams, AJ, Jones, N, Thomas, C, Stretton, A, Morgan, AR, Williams, KEM, Lovestone, S, Powell, JFF, Proitsi, P, Lupton, MK, Brayne, CEG, Rubinsztein, DC, Gill, M, Lawlor, BA, Lynch, A, Morgan, KN, Brown, KS, Passmore, PA, Craig, DA, McGuinness, BM, Johnston, JA, Todd, SA, Holmes, C, Mann, D, Smith, AD, Love, S , Kehoe, PGA, Hardy, JA, Guerreiro, RJ, Singleton, AB, Mead, S, Fox, NC, Rossor, MN, Collinge, JC, Maier, WA, Jessen, F, Heun, R, Schürmann, B, Ramírez, AL, Becker, T, Herold, C, Lacour, A, Drichel, D, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, JG, Dichgans, M, Frölich, L, Hampel, H, Hüll, MH, Rujescu, DAN, Goate, AM, Kauwe, JSK, Cruchaga, C, Nowotny, P, Morris, JCK, Mayo, K, Livingston, GA, Bass, NJ, Gurling, HMD, McQuillin, A, Gwilliam, RG, Deloukas, P, Nöthen, MM, Holmans, PA, O'Donovan, MC, Owen, MJ, Williams, JO, Stewart, R, Sham, PC, Lovestone, S & Powell, JF 2014, 'Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis', PLoS Medicine, vol. 11, no. 9. https://doi.org/10.1371/journal.pmed.1001713

Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis. / Proitsi, Petroula; Lupton, Michelle Katharine; Velayudhan, Latha; Newhouse, Stephen J.; Fogh, Isabella; Tsolaki, Magda N.; Daniilidou, Makrina; Pritchard, Megan; Kłoszewska, Iwona; Soininen, Hilkka S.; Mecocci, Patrizia; Vellas, Bruno J.; Williams, Julie I.; Harold, Denise H.; Sims, Rebecca J A; Gerrish, Amy; Chapman, Jade A.; Escott-Price, Valentina; Abraham, Richard J.; Hollingworth, Paul; Hamshere, Marian L.; Singh Pahwa, Jaspreet; Dowzell, Kimberley; Williams, Amy J.; Jones, Nicola; Thomas, Charlene; Stretton, Alexandra; Morgan, Angharad R.; Williams, Katherine Ellie M; Lovestone, Simon; Powell, John F F; Proitsi, Petroula; Lupton, Michelle K.; Brayne, Carol E G; Rubinsztein, David C.; Gill, Michael; Lawlor, Brian A.; Lynch, Aoibhinn; Morgan, Kevin N.; Brown, Kristelle S.; Passmore, Peter A.; Craig, David A.; McGuinness, Bernadette M.; Johnston, Janet A.; Todd, Stephen A.; Holmes, Clive; Mann, David; Smith, Ann David; Love, Seth ; Kehoe, Patrick Gavin Avin; Hardy, John Anthony; Guerreiro, Rita João; Singleton, Andrew B.; Mead, S.; Fox, Nick C.; Rossor, Martin N.; Collinge, John C.; Maier, Wolfgang A.; Jessen, Frank; Heun, Reinhard; Schürmann, Britta; Ramírez, Alfredo L.; Becker, Tim; Herold, Christine; Lacour, André; Drichel, Dmitriy; Van Den Bussche, Hendrik; Heuser, Isabella; Kornhuber, Johannes; Wiltfang, Jens G.; Dichgans, Martin; Frölich, Lutz; Hampel, Harald; Hüll, Michael H.; Rujescu, Dan A N; Goate, Alison M.; Kauwe, John S K; Cruchaga, Carlos; Nowotny, Petra; Morris, John Clay K; Mayo, Kevin; Livingston, Gill A.; Bass, Nicholas James; Gurling, Hugh Malcolm Douglas; McQuillin, Andrew; Gwilliam, Rhian G.; Deloukas, Panos; Nöthen, Markus M.; Holmans, Peter A.; O'Donovan, M. C.; Owen, Michael John; Williams, Julie O.; Stewart, Robert; Sham, Pak Chung; Lovestone, Simon; Powell, John F.

In: PLoS Medicine, Vol. 11, No. 9, 01.01.2014.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

AU - Proitsi, Petroula

AU - Lupton, Michelle Katharine

AU - Velayudhan, Latha

AU - Newhouse, Stephen J.

AU - Fogh, Isabella

AU - Tsolaki, Magda N.

AU - Daniilidou, Makrina

AU - Pritchard, Megan

AU - Kłoszewska, Iwona

AU - Soininen, Hilkka S.

AU - Mecocci, Patrizia

AU - Vellas, Bruno J.

AU - Williams, Julie I.

AU - Harold, Denise H.

AU - Sims, Rebecca J A

AU - Gerrish, Amy

AU - Chapman, Jade A.

AU - Escott-Price, Valentina

AU - Abraham, Richard J.

AU - Hollingworth, Paul

AU - Hamshere, Marian L.

AU - Singh Pahwa, Jaspreet

AU - Dowzell, Kimberley

AU - Williams, Amy J.

AU - Jones, Nicola

AU - Thomas, Charlene

AU - Stretton, Alexandra

AU - Morgan, Angharad R.

AU - Williams, Katherine Ellie M

AU - Lovestone, Simon

AU - Powell, John F F

AU - Proitsi, Petroula

AU - Lupton, Michelle K.

AU - Brayne, Carol E G

AU - Rubinsztein, David C.

AU - Gill, Michael

AU - Lawlor, Brian A.

AU - Lynch, Aoibhinn

AU - Morgan, Kevin N.

AU - Brown, Kristelle S.

AU - Passmore, Peter A.

AU - Craig, David A.

AU - McGuinness, Bernadette M.

AU - Johnston, Janet A.

AU - Todd, Stephen A.

AU - Holmes, Clive

AU - Mann, David

AU - Smith, Ann David

AU - Love, Seth

AU - Kehoe, Patrick Gavin Avin

AU - Hardy, John Anthony

AU - Guerreiro, Rita João

AU - Singleton, Andrew B.

AU - Mead, S.

AU - Fox, Nick C.

AU - Rossor, Martin N.

AU - Collinge, John C.

AU - Maier, Wolfgang A.

AU - Jessen, Frank

AU - Heun, Reinhard

AU - Schürmann, Britta

AU - Ramírez, Alfredo L.

AU - Becker, Tim

AU - Herold, Christine

AU - Lacour, André

AU - Drichel, Dmitriy

AU - Van Den Bussche, Hendrik

AU - Heuser, Isabella

AU - Kornhuber, Johannes

AU - Wiltfang, Jens G.

AU - Dichgans, Martin

AU - Frölich, Lutz

AU - Hampel, Harald

AU - Hüll, Michael H.

AU - Rujescu, Dan A N

AU - Goate, Alison M.

AU - Kauwe, John S K

AU - Cruchaga, Carlos

AU - Nowotny, Petra

AU - Morris, John Clay K

AU - Mayo, Kevin

AU - Livingston, Gill A.

AU - Bass, Nicholas James

AU - Gurling, Hugh Malcolm Douglas

AU - McQuillin, Andrew

AU - Gwilliam, Rhian G.

AU - Deloukas, Panos

AU - Nöthen, Markus M.

AU - Holmans, Peter A.

AU - O'Donovan, M. C.

AU - Owen, Michael John

AU - Williams, Julie O.

AU - Stewart, Robert

AU - Sham, Pak Chung

AU - Lovestone, Simon

AU - Powell, John F.

PY - 2014/1/1

Y1 - 2014/1/1

UR - http://www.scopus.com/inward/record.url?scp=84907956274&partnerID=8YFLogxK

U2 - 10.1371/journal.pmed.1001713

DO - 10.1371/journal.pmed.1001713

M3 - Article (Academic Journal)

C2 - 25226301

AN - SCOPUS:84907956274

VL - 11

JO - PLoS Medicine

JF - PLoS Medicine

SN - 1549-1277

IS - 9

ER -