In this chapter we summarize a broad range of research studies that aim to improve our understanding of the genetic risk and etiology of psychosis. We begin by discussing early, mainly unsuccessful, attempts at identifying causal genetic factors through candidate gene and linkage studies. We then highlight the major advances achieved over the last decade by genome-wide association studies, including identification of common risk loci, quantifying genetic correlations between psychiatric disorders, and use of polygenic scores to explore phenotypic manifestation of genetic risk and for development of disease prediction models. We then summarize the main findings from copy number and rare variant studies and end with a discussion of the use of genetic factors in Mendelian randomization to improve causal inference.
|Title of host publication||Risk Factors for Psychosis|
|Subtitle of host publication||Paradigms, Mechanisms, and Prevention|
|Publication status||Published - 2020|
Jones, H. J., Zammit, S., & Walters, J. T. (2020). Genetic studies of psychosis. In Risk Factors for Psychosis: Paradigms, Mechanisms, and Prevention (pp. 183-209). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-813201-2.00010-7