Genetic variants influencing circulating lipid levels and risk of coronary artery disease

Dawn M Waterworth, Sally L Ricketts, Kijoung Song, Li Chen, Jing Hua Zhao, Samuli Ripatti, Yurii S Aulchenko, Weihua Zhang, Xin Yuan, Noha Lim, Jian'an Luan, Sofie Ashford, Eleanor Wheeler, Elizabeth H Young, David Hadley, John R Thompson, Peter S Braund, Toby Johnson, Maksim Struchalin, Ida SurakkaRobert Luben, Kay-Tee Khaw, Sheila A Rodwell, Ruth J F Loos, S Matthijs Boekholdt, Michael Inouye, Panagiotis Deloukas, Paul Elliott, David Schlessinger, Serena Sanna, Angelo Scuteri, Anne Jackson, Karen L Mohlke, Jaako Tuomilehto, Robert Roberts, Alexandre Stewart, Y Antero Kesäniemi, Robert W Mahley, Scott M Grundy, Wendy McArdle, Lon Cardon, Gérard Waeber, Peter Vollenweider, John C Chambers, Michael Boehnke, Gonçalo R Abecasis, Veikko Salomaa, Marjo-Riitta Järvelin, Aimo Ruokonen, Inês Barroso, Wellcome Trust Case Control Consortium

Research output: Contribution to journalArticle (Academic Journal)peer-review

296 Citations (Scopus)

Abstract

Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.
Original languageEnglish
Pages (from-to)2264-76
Number of pages13
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume30
Issue number11
DOIs
Publication statusPublished - 2010

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