Genetic variants influencing circulating lipid levels and risk of coronary artery disease

Dawn M Waterworth; Sally L Ricketts; Kijoung Song; Li Chen; Jing Hua Zhao; Samuli Ripatti; Yurii S Aulchenko; Weihua Zhang; Xin Yuan; Noha Lim; Jian'an Luan; Sofie Ashford; Eleanor Wheeler; Elizabeth H Young; David Hadley; John R Thompson; Peter S Braund; Toby Johnson; Maksim Struchalin; Ida Surakka; Robert Luben; Kay-Tee Khaw; Sheila A Rodwell; Ruth J F Loos; S Matthijs Boekholdt; Michael Inouye; Panagiotis Deloukas; Paul Elliott; David Schlessinger; Serena Sanna; Angelo Scuteri; Anne Jackson; Karen L Mohlke; Jaako Tuomilehto; Robert Roberts; Alexandre Stewart; Y Antero Kesäniemi; Robert W Mahley; Scott M Grundy; Wendy McArdle; Lon Cardon; Gérard Waeber; Peter Vollenweider; John C Chambers; Michael Boehnke; Gonçalo R Abecasis; Veikko Salomaa; Marjo-Riitta Järvelin; Aimo Ruokonen; Inês Barroso; Wellcome Trust Case Control Consortium

doi:10.1161/ATVBAHA.109.201020

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

Dawn M Waterworth
, Sally L Ricketts
, Kijoung Song
, Li Chen
, Jing Hua Zhao
, Samuli Ripatti
, Yurii S Aulchenko
, Weihua Zhang
, Xin Yuan
, Noha Lim
, Jian'an Luan
, Sofie Ashford
, Eleanor Wheeler
, Elizabeth H Young
, David Hadley
, John R Thompson
, Peter S Braund
, Toby Johnson
, Maksim Struchalin
, Ida Surakka

Robert Luben, Kay-Tee Khaw, Sheila A Rodwell, Ruth J F Loos, S Matthijs Boekholdt, Michael Inouye, Panagiotis Deloukas, Paul Elliott, David Schlessinger, Serena Sanna, Angelo Scuteri, Anne Jackson, Karen L Mohlke, Jaako Tuomilehto, Robert Roberts, Alexandre Stewart, Y Antero Kesäniemi, Robert W Mahley, Scott M Grundy, Wendy McArdle, Lon Cardon, Gérard Waeber, Peter Vollenweider, John C Chambers, Michael Boehnke, Gonçalo R Abecasis, Veikko Salomaa, Marjo-Riitta Järvelin, Aimo Ruokonen, Inês Barroso, Wellcome Trust Case Control Consortium

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

373 Citations (Scopus)

Abstract

Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.

Original language	English
Pages (from-to)	2264-76
Number of pages	13
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	30
Issue number	11
DOIs	https://doi.org/10.1161/ATVBAHA.109.201020
Publication status	Published - 2010

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Waterworth, D. M., Ricketts, S. L., Song, K., Chen, L., Zhao, J. H., Ripatti, S., Aulchenko, Y. S., Zhang, W., Yuan, X., Lim, N., Luan, J., Ashford, S., Wheeler, E., Young, E. H., Hadley, D., Thompson, J. R., Braund, P. S., Johnson, T., Struchalin, M., ... Wellcome Trust Case Control Consortium (2010). Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(11), 2264-76. https://doi.org/10.1161/ATVBAHA.109.201020

@article{1714587da0d74e47a87ba04d4fe0065b,

title = "Genetic variants influencing circulating lipid levels and risk of coronary artery disease",

abstract = "Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.",

author = "Waterworth, \{Dawn M\} and Ricketts, \{Sally L\} and Kijoung Song and Li Chen and Zhao, \{Jing Hua\} and Samuli Ripatti and Aulchenko, \{Yurii S\} and Weihua Zhang and Xin Yuan and Noha Lim and Jian'an Luan and Sofie Ashford and Eleanor Wheeler and Young, \{Elizabeth H\} and David Hadley and Thompson, \{John R\} and Braund, \{Peter S\} and Toby Johnson and Maksim Struchalin and Ida Surakka and Robert Luben and Kay-Tee Khaw and Rodwell, \{Sheila A\} and Loos, \{Ruth J F\} and Boekholdt, \{S Matthijs\} and Michael Inouye and Panagiotis Deloukas and Paul Elliott and David Schlessinger and Serena Sanna and Angelo Scuteri and Anne Jackson and Mohlke, \{Karen L\} and Jaako Tuomilehto and Robert Roberts and Alexandre Stewart and Kes{\"a}niemi, \{Y Antero\} and Mahley, \{Robert W\} and Grundy, \{Scott M\} and Wendy McArdle and Lon Cardon and G{\'e}rard Waeber and Peter Vollenweider and Chambers, \{John C\} and Michael Boehnke and Abecasis, \{Gon{\c c}alo R\} and Veikko Salomaa and Marjo-Riitta J{\"a}rvelin and Aimo Ruokonen and In{\^e}s Barroso and \{Wellcome Trust Case Control Consortium\}",

year = "2010",

doi = "10.1161/ATVBAHA.109.201020",

language = "English",

volume = "30",

pages = "2264--76",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1524-4636",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

Waterworth, DM, Ricketts, SL, Song, K, Chen, L, Zhao, JH, Ripatti, S, Aulchenko, YS, Zhang, W, Yuan, X, Lim, N, Luan, J, Ashford, S, Wheeler, E, Young, EH, Hadley, D, Thompson, JR, Braund, PS, Johnson, T, Struchalin, M, Surakka, I, Luben, R, Khaw, K-T, Rodwell, SA, Loos, RJF, Boekholdt, SM, Inouye, M, Deloukas, P, Elliott, P, Schlessinger, D, Sanna, S, Scuteri, A, Jackson, A, Mohlke, KL, Tuomilehto, J, Roberts, R, Stewart, A, Kesäniemi, YA, Mahley, RW, Grundy, SM, McArdle, W, Cardon, L, Waeber, G, Vollenweider, P, Chambers, JC, Boehnke, M, Abecasis, GR, Salomaa, V, Järvelin, M-R, Ruokonen, A, Barroso, I & Wellcome Trust Case Control Consortium 2010, 'Genetic variants influencing circulating lipid levels and risk of coronary artery disease', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 11, pp. 2264-76. https://doi.org/10.1161/ATVBAHA.109.201020

TY - JOUR

T1 - Genetic variants influencing circulating lipid levels and risk of coronary artery disease

AU - Waterworth, Dawn M

AU - Ricketts, Sally L

AU - Song, Kijoung

AU - Chen, Li

AU - Zhao, Jing Hua

AU - Ripatti, Samuli

AU - Aulchenko, Yurii S

AU - Zhang, Weihua

AU - Yuan, Xin

AU - Lim, Noha

AU - Luan, Jian'an

AU - Ashford, Sofie

AU - Wheeler, Eleanor

AU - Young, Elizabeth H

AU - Hadley, David

AU - Thompson, John R

AU - Braund, Peter S

AU - Johnson, Toby

AU - Struchalin, Maksim

AU - Surakka, Ida

AU - Luben, Robert

AU - Khaw, Kay-Tee

AU - Rodwell, Sheila A

AU - Loos, Ruth J F

AU - Boekholdt, S Matthijs

AU - Inouye, Michael

AU - Deloukas, Panagiotis

AU - Elliott, Paul

AU - Schlessinger, David

AU - Sanna, Serena

AU - Scuteri, Angelo

AU - Jackson, Anne

AU - Mohlke, Karen L

AU - Tuomilehto, Jaako

AU - Roberts, Robert

AU - Stewart, Alexandre

AU - Kesäniemi, Y Antero

AU - Mahley, Robert W

AU - Grundy, Scott M

AU - McArdle, Wendy

AU - Cardon, Lon

AU - Waeber, Gérard

AU - Vollenweider, Peter

AU - Chambers, John C

AU - Boehnke, Michael

AU - Abecasis, Gonçalo R

AU - Salomaa, Veikko

AU - Järvelin, Marjo-Riitta

AU - Ruokonen, Aimo

AU - Barroso, Inês

AU - Wellcome Trust Case Control Consortium

PY - 2010

Y1 - 2010

N2 - Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.

AB - Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.

U2 - 10.1161/ATVBAHA.109.201020

DO - 10.1161/ATVBAHA.109.201020

M3 - Article (Academic Journal)

C2 - 20864672

SN - 1524-4636

VL - 30

SP - 2264

EP - 2276

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 11

ER -

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

Abstract

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