Abstract
In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences’.
| Original language | English |
|---|---|
| Article number | 20170162 |
| Number of pages | 10 |
| Journal | Philosophical Transactions B: Biological Sciences |
| Volume | 373 |
| Issue number | 1744 |
| Early online date | 26 Feb 2018 |
| DOIs | |
| Publication status | Published - 19 Apr 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research Groups and Themes
- Brain and Behaviour
- Tobacco and Alcohol
- Physical and Mental Health
- TARG
Keywords
- Behavioural traits
- GWAS
- Heritability
- Mendelian randomization
- Personality
- Temperament
Fingerprint
Dive into the research topics of 'Genetics of biologically based psychological differences'. Together they form a unique fingerprint.Projects
- 2 Finished
-
MRC UoB UNITE Unit - Programme 6
Munafo, M. R. (Principal Investigator) & Munafo, M. R. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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