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Genetics of biologically based psychological differences

Hannah Sallis*, George Davey Smith, Marcus R. Munafò

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)
440 Downloads (Pure)

Abstract

In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences’.

Original languageEnglish
Article number20170162
Number of pages10
JournalPhilosophical Transactions B: Biological Sciences
Volume373
Issue number1744
Early online date26 Feb 2018
DOIs
Publication statusPublished - 19 Apr 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Research Groups and Themes

  • Brain and Behaviour
  • Tobacco and Alcohol
  • Physical and Mental Health
  • TARG

Keywords

  • Behavioural traits
  • GWAS
  • Heritability
  • Mendelian randomization
  • Personality
  • Temperament

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  • MRC UoB UNITE Unit - Programme 6

    Munafo, M. R. (Principal Investigator) & Munafo, M. R. (Principal Investigator)

    1/06/1331/03/18

    Project: Research

  • MRC UoB UNITE Unit - Programme 1

    Davey Smith, G. (Principal Investigator)

    1/06/1331/03/18

    Project: Research

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