Projects per year
Abstract
BACKGROUND: Head circumference is associated with intelligence and tracks from childhood into adulthood.
METHODS: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.
RESULTS: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.
CONCLUSIONS: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
Original language | English |
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Pages (from-to) | 124 |
Journal | BMC Medical Genomics |
Volume | 15 |
Issue number | 124 |
DOIs | |
Publication status | Published - 4 Jun 2022 |
Bibliographical note
© 2022. The Author(s).Research Groups and Themes
- Bristol Population Health Science Institute
Keywords
- Adult
- Child
- Cognition
- Educational Status
- Genome-Wide Association Study/methods
- Humans
- Phenotype
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Dive into the research topics of 'Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes'. Together they form a unique fingerprint.Projects
- 1 Finished
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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research