Genital chlamydia trachomatis infections clear more slowly in men Than women, but are less likely to become established

Joanna Lewis*, Malcolm J. Price, Paddy J. Horner, Peter J. White

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Abstract

Background. Rigorous estimates for clearance rates of untreated chlamydia infections are important for understanding chlamydia epidemiology and designing control interventions, but were previously only available for women. Methods. We used data from published studies of chlamydia-infected men who were retested at a later date without having received treatment. Our analysis allowed new infections to take one of 1, 2, or 3 courses, each clearing at a different rate. We determined which of these 3 models had the most empirical support. Results. The best-fitting model had 2 courses of infection in men, as was previously found for women: "slow-clearing" and "fast-clearing." Only 68% (57%-78%) (posterior median and 95% credible interval [CrI]) of incident infections in men were slow-clearing, vs 77% (69%-84%) in women. The slow clearance rate in men (based on 6 months' follow-up) was 0.35 (.05-1.15) year-1 (posterior median and 95% CrI), corresponding to mean infection duration 2.84 (.87-18.79) years. This compares to 1.35 (1.13-1.63) years in women. Conclusions. Our estimated clearance rate is slower than previously assumed. Fewer infections become established in men than women but once established, they clear more slowly. This study provides an improved description of chlamydia's natural history to inform public health decision making. We describe how further data collection could reduce uncertainty in estimates.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalJournal of Infectious Diseases
Volume216
Issue number2
DOIs
Publication statusPublished - 15 Jul 2017

Keywords

  • Bayesian inference
  • Chlamydia
  • Evidence synthesis
  • Natural history
  • Sexually transmitted diseases

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