Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases

V Plagnol; JM Howson; DJ Smyth; N Walker; JP Hafler; C Wallace; H Stevens; L Jackson; MJ Simmonds; Consortium Type 1 Diabetes Genetics; PJ Bingley; SC Gough; JA Todd

doi:10.1371/journal.pgen.1002216

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases

V Plagnol, JM Howson, DJ Smyth, N Walker, JP Hafler, C Wallace, H Stevens, L Jackson, MJ Simmonds, Consortium Type 1 Diabetes Genetics, PJ Bingley, SC Gough, JA Todd

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Abstract

The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoantibody measurements. We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis. Two loci passed a stringent genome-wide significance level (p

Translated title of the contribution	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases
Original language	English
Journal	PLoS Genetics
Volume	7(8):e1002216
DOIs	https://doi.org/10.1371/journal.pgen.1002216
Publication status	Published - Aug 2011

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title = "Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases",

abstract = "The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoantibody measurements. We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis. Two loci passed a stringent genome-wide significance level (p",

author = "V Plagnol and JM Howson and DJ Smyth and N Walker and JP Hafler and C Wallace and H Stevens and L Jackson and MJ Simmonds and {Type 1 Diabetes Genetics}, Consortium and PJ Bingley and SC Gough and JA Todd",

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doi = "10.1371/journal.pgen.1002216",

language = "English",

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T1 - Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases

AU - Plagnol, V

AU - Howson, JM

AU - Smyth, DJ

AU - Walker, N

AU - Hafler, JP

AU - Wallace, C

AU - Stevens, H

AU - Jackson, L

AU - Simmonds, MJ

AU - Type 1 Diabetes Genetics, Consortium

AU - Bingley, PJ

AU - Gough, SC

AU - Todd, JA

PY - 2011/8

Y1 - 2011/8

N2 - The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoantibody measurements. We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis. Two loci passed a stringent genome-wide significance level (p

AB - The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoantibody measurements. We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis. Two loci passed a stringent genome-wide significance level (p

U2 - 10.1371/journal.pgen.1002216

DO - 10.1371/journal.pgen.1002216

M3 - Article (Academic Journal)

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SN - 1553-7404

VL - 7(8):e1002216

JO - PLoS Genetics

JF - PLoS Genetics

ER -

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases

Abstract

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