Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

María Soler Artigas; Daan W Loth; Louise V Wain; Sina A Gharib; Ma'en Obeidat; Wenbo Tang; Guangju Zhai; Jing Hua Zhao; Albert Vernon Smith; Jennifer E Huffman; Eva Albrecht; Catherine M Jackson; David M Evans; Gemma Cadby; Myriam Fornage; Ani Manichaikul; Lorna M Lopez; Toby Johnson; Melinda C Aldrich; Thor Aspelund; Inês Barroso; Harry Campbell; Patricia A Cassano; David J Couper; Gudny Eiriksdottir; Nora Franceschini; Melissa Garcia; Christian Gieger; Gauti Kjartan Gislason; Ivica Grkovic; Christopher J Hammond; Dana B Hancock; Tamara B Harris; Adaikalavan Ramasamy; Susan R Heckbert; Markku Heliövaara; Georg Homuth; Pirro G Hysi; Alan L James; Stipan Jankovic; Shah Ebrahim; Raquel Granell; Sarah E Harris; John Henderson; Susan M Ring; George Davey Smith; Wendy L McArdle; Lyle J Palmer; Debbie A Lawlor; Richard W Morris; International Lung Cancer Consortium

doi:10.1038/ng.941

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

María Soler Artigas, Daan W Loth, Louise V Wain, Sina A Gharib, Ma'en Obeidat, Wenbo Tang, Guangju Zhai, Jing Hua Zhao, Albert Vernon Smith, Jennifer E Huffman, Eva Albrecht, Catherine M Jackson, David M Evans, Gemma Cadby, Myriam Fornage, Ani Manichaikul, Lorna M Lopez, Toby Johnson, Melinda C Aldrich, Thor AspelundInês Barroso, Harry Campbell, Patricia A Cassano, David J Couper, Gudny Eiriksdottir, Nora Franceschini, Melissa Garcia, Christian Gieger, Gauti Kjartan Gislason, Ivica Grkovic, Christopher J Hammond, Dana B Hancock, Tamara B Harris, Adaikalavan Ramasamy, Susan R Heckbert, Markku Heliövaara, Georg Homuth, Pirro G Hysi, Alan L James, Stipan Jankovic, Shah Ebrahim, Raquel Granell, Sarah E Harris, John Henderson, Susan M Ring, George Davey Smith, Wendy L McArdle, Lyle J Palmer, Debbie A Lawlor, Richard W Morris, International Lung Cancer Consortium

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Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Original language	English
Pages (from-to)	1082-90
Number of pages	9
Journal	Nature Genetics
Volume	43
Issue number	11
DOIs	https://doi.org/10.1038/ng.941
Publication status	Published - 2011

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA
Henderson, A. J. W. (Principal Investigator)
1/10/06 → 1/10/10
Project: Research

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Soler Artigas, M., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E., Albrecht, E., Jackson, C. M., Evans, D. M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L. M., Johnson, T., Aldrich, M. C., ... International Lung Cancer Consortium (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-90. https://doi.org/10.1038/ng.941

@article{e2e3f854b4e24a78a77a789a68af1337,

title = "Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function",

abstract = "Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.",

author = "{Soler Artigas}, Mar{\'i}a and Loth, {Daan W} and Wain, {Louise V} and Gharib, {Sina A} and Ma'en Obeidat and Wenbo Tang and Guangju Zhai and Zhao, {Jing Hua} and Smith, {Albert Vernon} and Huffman, {Jennifer E} and Eva Albrecht and Jackson, {Catherine M} and Evans, {David M} and Gemma Cadby and Myriam Fornage and Ani Manichaikul and Lopez, {Lorna M} and Toby Johnson and Aldrich, {Melinda C} and Thor Aspelund and In{\^e}s Barroso and Harry Campbell and Cassano, {Patricia A} and Couper, {David J} and Gudny Eiriksdottir and Nora Franceschini and Melissa Garcia and Christian Gieger and Gislason, {Gauti Kjartan} and Ivica Grkovic and Hammond, {Christopher J} and Hancock, {Dana B} and Harris, {Tamara B} and Adaikalavan Ramasamy and Heckbert, {Susan R} and Markku Heli{\"o}vaara and Georg Homuth and Hysi, {Pirro G} and James, {Alan L} and Stipan Jankovic and Shah Ebrahim and Raquel Granell and Harris, {Sarah E} and John Henderson and Ring, {Susan M} and Smith, {George Davey} and McArdle, {Wendy L} and Palmer, {Lyle J} and Lawlor, {Debbie A} and Morris, {Richard W} and {International Lung Cancer Consortium}",

year = "2011",

doi = "10.1038/ng.941",

language = "English",

volume = "43",

pages = "1082--90",

journal = "Nature Genetics",

issn = "1546-1718",

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number = "11",

}

Soler Artigas, M, Loth, DW, Wain, LV, Gharib, SA, Obeidat, M, Tang, W, Zhai, G, Zhao, JH, Smith, AV, Huffman, JE, Albrecht, E, Jackson, CM, Evans, DM, Cadby, G, Fornage, M, Manichaikul, A, Lopez, LM, Johnson, T, Aldrich, MC, Aspelund, T, Barroso, I, Campbell, H, Cassano, PA, Couper, DJ, Eiriksdottir, G, Franceschini, N, Garcia, M, Gieger, C, Gislason, GK, Grkovic, I, Hammond, CJ, Hancock, DB, Harris, TB, Ramasamy, A, Heckbert, SR, Heliövaara, M, Homuth, G, Hysi, PG, James, AL, Jankovic, S, Ebrahim, S, Granell, R, Harris, SE, Henderson, J, Ring, SM , Smith, GD, McArdle, WL, Palmer, LJ, Lawlor, DA, Morris, RW & International Lung Cancer Consortium 2011, 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function', Nature Genetics, vol. 43, no. 11, pp. 1082-90. https://doi.org/10.1038/ng.941

TY - JOUR

T1 - Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

AU - Soler Artigas, María

AU - Loth, Daan W

AU - Wain, Louise V

AU - Gharib, Sina A

AU - Obeidat, Ma'en

AU - Tang, Wenbo

AU - Zhai, Guangju

AU - Zhao, Jing Hua

AU - Smith, Albert Vernon

AU - Huffman, Jennifer E

AU - Albrecht, Eva

AU - Jackson, Catherine M

AU - Evans, David M

AU - Cadby, Gemma

AU - Fornage, Myriam

AU - Manichaikul, Ani

AU - Lopez, Lorna M

AU - Johnson, Toby

AU - Aldrich, Melinda C

AU - Aspelund, Thor

AU - Barroso, Inês

AU - Campbell, Harry

AU - Cassano, Patricia A

AU - Couper, David J

AU - Eiriksdottir, Gudny

AU - Franceschini, Nora

AU - Garcia, Melissa

AU - Gieger, Christian

AU - Gislason, Gauti Kjartan

AU - Grkovic, Ivica

AU - Hammond, Christopher J

AU - Hancock, Dana B

AU - Harris, Tamara B

AU - Ramasamy, Adaikalavan

AU - Heckbert, Susan R

AU - Heliövaara, Markku

AU - Homuth, Georg

AU - Hysi, Pirro G

AU - James, Alan L

AU - Jankovic, Stipan

AU - Ebrahim, Shah

AU - Granell, Raquel

AU - Harris, Sarah E

AU - Henderson, John

AU - Ring, Susan M

AU - Smith, George Davey

AU - McArdle, Wendy L

AU - Palmer, Lyle J

AU - Lawlor, Debbie A

AU - Morris, Richard W

AU - International Lung Cancer Consortium

PY - 2011

Y1 - 2011

N2 - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

AB - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

U2 - 10.1038/ng.941

DO - 10.1038/ng.941

M3 - Article (Academic Journal)

C2 - 21946350

SN - 1546-1718

VL - 43

SP - 1082

EP - 1090

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA

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