Genome wide association study identifies genetic associations with perceived age

Victoria Roberts, Barry Main, Nicholas J Timpson, Simon Haworth

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Failure of dermal protection or repair mechanisms might lead to visibly aged skin. The study aimed to identify genetic associations with perceived age. A genome-wide association study was undertaken in 423,992 adult participants of UK Biobank, using questionnaire data on perceived age and genetic data imputed to the Haplotype Reference Consortium imputation panel. Seventy-four to our knowledge previously unreported and independent associated genetic loci were identified (P<5x10-8), which were enriched for cell signaling pathways including the NEK6 and SMAD2 subnetworks. Common genetic variation was estimated to account for 14% of variation in perceived age and the heritability of perceived age was partially shared with that of 75 other traits including multiple traits representing adiposity, suggesting that perceived age may be a useful proxy trait in genetic association studies.
Original languageEnglish
JournalJournal of Investigative Dermatology
DOIs
Publication statusAccepted/In press - 4 Mar 2020

Structured keywords

  • ICEP

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