Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

D Pillas, C Hoggart, DM Evans, PF O'Reilly, K Sipilä, R Lähdesmäki, IY Millwood, M Kaakinen, G Netuveli, D Blane, P Charoen, U Sovio, A Pouta, N Freimer, AL Hartikainen, J Laitinen, S Vaara, MUB Glaser, P Crawford, NJ TimpsonSM Ring, G Deng, W Zhang, MI McCarthy, P Deloukas, L Peltonen, P Elliott, LJM Coin, G Davey Smith, MR Jarvelin

Research output: Contribution to journalArticle (Academic Journal)peer-review

50 Citations (Scopus)

Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P
Translated title of the contributionGenome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy
Original languageEnglish
Pages (from-to)1 - 7
Number of pages7
JournalPLoS Genetics
Volume6(2)
DOIs
Publication statusPublished - Feb 2010

Bibliographical note

Publisher: Public Library of Science
Other: E-Publication

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