Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

D Pillas; C Hoggart; DM Evans; PF O'Reilly; K Sipilä; R Lähdesmäki; IY Millwood; M Kaakinen; G Netuveli; D Blane; P Charoen; U Sovio; A Pouta; N Freimer; AL Hartikainen; J Laitinen; S Vaara; MUB Glaser; P Crawford; NJ Timpson; SM Ring; G Deng; W Zhang; MI McCarthy; P Deloukas; L Peltonen; P Elliott; LJM Coin; G Davey Smith; MR Jarvelin

doi:10.1371/journal.pgen.1000856

Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

D Pillas
, C Hoggart
, DM Evans
, PF O'Reilly
, K Sipilä
, R Lähdesmäki
, IY Millwood
, M Kaakinen
, G Netuveli
, D Blane
, P Charoen
, U Sovio
, A Pouta
, N Freimer
, AL Hartikainen
, J Laitinen
, S Vaara
, MUB Glaser
, P Crawford
, NJ Timpson

SM Ring, G Deng, W Zhang, MI McCarthy, P Deloukas, L Peltonen, P Elliott, LJM Coin, G Davey Smith, MR Jarvelin

Research output: Contribution to journal › Article (Academic Journal) › peer-review

76 Citations (Scopus)

Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P

Translated title of the contribution	Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy
Original language	English
Pages (from-to)	1 - 7
Number of pages	7
Journal	PLOS Genetics
Volume	6(2)
DOIs	https://doi.org/10.1371/journal.pgen.1000856
Publication status	Published - Feb 2010

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Publisher: Public Library of Science
Other: E-Publication

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Pillas, D., Hoggart, C., Evans, DM., O'Reilly, PF., Sipilä, K., Lähdesmäki, R., Millwood, IY., Kaakinen, M., Netuveli, G., Blane, D., Charoen, P., Sovio, U., Pouta, A., Freimer, N., Hartikainen, AL., Laitinen, J., Vaara, S., Glaser, MUB., Crawford, P., ... Jarvelin, MR. (2010). Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy. PLOS Genetics, 6(2), 1 - 7. https://doi.org/10.1371/journal.pgen.1000856

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title = "Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy",

abstract = "Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P",

author = "D Pillas and C Hoggart and DM Evans and PF O'Reilly and K Sipil{\"a} and R L{\"a}hdesm{\"a}ki and IY Millwood and M Kaakinen and G Netuveli and D Blane and P Charoen and U Sovio and A Pouta and N Freimer and AL Hartikainen and J Laitinen and S Vaara and MUB Glaser and P Crawford and NJ Timpson and SM Ring and G Deng and W Zhang and MI McCarthy and P Deloukas and L Peltonen and P Elliott and LJM Coin and \{Davey Smith\}, G and MR Jarvelin",

note = "Publisher: Public Library of Science Other: E-Publication",

year = "2010",

month = feb,

doi = "10.1371/journal.pgen.1000856",

language = "English",

volume = "6(2)",

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Pillas, D, Hoggart, C, Evans, DM, O'Reilly, PF, Sipilä, K, Lähdesmäki, R, Millwood, IY, Kaakinen, M, Netuveli, G, Blane, D, Charoen, P, Sovio, U, Pouta, A, Freimer, N, Hartikainen, AL, Laitinen, J, Vaara, S, Glaser, MUB, Crawford, P, Timpson, NJ , Ring, SM, Deng, G, Zhang, W, McCarthy, MI, Deloukas, P, Peltonen, L, Elliott, P, Coin, LJM, Davey Smith, G & Jarvelin, MR 2010, 'Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy', PLOS Genetics, vol. 6(2), pp. 1 - 7. https://doi.org/10.1371/journal.pgen.1000856

TY - JOUR

T1 - Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

AU - Pillas, D

AU - Hoggart, C

AU - Evans, DM

AU - O'Reilly, PF

AU - Sipilä, K

AU - Lähdesmäki, R

AU - Millwood, IY

AU - Kaakinen, M

AU - Netuveli, G

AU - Blane, D

AU - Charoen, P

AU - Sovio, U

AU - Pouta, A

AU - Freimer, N

AU - Hartikainen, AL

AU - Laitinen, J

AU - Vaara, S

AU - Glaser, MUB

AU - Crawford, P

AU - Timpson, NJ

AU - Ring, SM

AU - Deng, G

AU - Zhang, W

AU - McCarthy, MI

AU - Deloukas, P

AU - Peltonen, L

AU - Elliott, P

AU - Coin, LJM

AU - Davey Smith, G

AU - Jarvelin, MR

N1 - Publisher: Public Library of Science Other: E-Publication

PY - 2010/2

Y1 - 2010/2

N2 - Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P

AB - Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P

U2 - 10.1371/journal.pgen.1000856

DO - 10.1371/journal.pgen.1000856

M3 - Article (Academic Journal)

C2 - 20195514

SN - 1553-7404

VL - 6(2)

SP - 1

EP - 7

JO - PLOS Genetics

JF - PLOS Genetics

ER -

Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Abstract

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