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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Research output: Contribution to journalArticle

  • Johannes Waage
  • Marie Standl
  • John A Curtin
  • Leon E Jessen
  • Jonathan Thorsen
  • Chao Tian
  • Nathan Schoettler
  • the 23 and Me Research Team
  • AAGC Collaborators
Original languageEnglish
Pages (from-to)1072-1080
Number of pages9
JournalNature Genetics
Volume50
Issue number8
Early online date16 Jul 2018
DOIs
DateAccepted/In press - 10 May 2018
DateE-pub ahead of print - 16 Jul 2018
DatePublished (current) - Aug 2018

Abstract

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, and with increasing incidence in westernized countries.1,2 To elucidate the genetic architecture and understand disease mechanisms of allergic rhinitis, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implied genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants of importance for antigen binding. We further performed GWASs of allergic sensitization against inhalant allergens and non-allergic rhinitis suggesting shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Springer Nature at https://www.nature.com/articles/s41588-018-0157-1 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 2 MB, PDF document

  • Supplementary information PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Springer Nature at https://www.nature.com/articles/s41588-018-0157-1 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 30 MB, PDF document

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