Genomic epidemiology of third-generation cephalosporin-resistant <i>Escherichia coli</i> from Argentinian pig and dairy farms reveals animal-specific patterns of co-resistance and resistance mechanisms

Oliver Mounsey, Laura Marchetti, Julián Parada, Laura V. Alarcón, Florencia Aliverti, Matthew B. Avison, Carlos S. Ayala, Cristina Ballesteros, Caroline M. Best, Judy Bettridge, Andrea Buchamer, Daniel Buldain, Alicia Carranza, Maite Corti Isgro, David Demeritt, Maria Paula Escobar, Lihuel Gortari Castillo, María Jaureguiberry, Mariana F. Lucas, L. Vanina MadozMaría José Marconi, Nicolás Moiso, Hernán D. Nievas, Marco A. Ramirez Montes De Oca, Carlos Reding-Roman, Kristen K. Reyher, Lucy Vass, Sara Williams, José Giraudo, R. Luzbel De La Sota, Nora Mestorino, Fabiana A. Moredo, Matías Pellegrino

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Little is known about the ecology of critically important antibiotic resistance among bacteria with the potential to be opportunistic human pathogens (e.g., Escherichia coli) on South American farms. By studying 70 pig and dairy cattle farms in central-eastern Argentina, we identified that third-generation cephalosporin resistance (3GC-R) in E. coli was mediated by mechanisms seen more often in certain species and that 3GC-R pig E. coli were more likely to be co-resistant to florfenicol and amoxicillin/clavulanate. This suggests that on-farm antibiotic usage is key to selecting the types of E. coli present on these farms. 3GC-R E. coli and 3GC-R plasmids were diverse, suggestive of long-term circulation in this region. We identified the de novo mobilization of the resistance gene bla ROB from pig pathogens into E. coli on a novel mobile genetic element, which shows the importance of surveying poorly studied regions for antibiotic resistance that might impact human health.
Original languageEnglish
JournalApplied and Environmental Microbiology
Volume90
Issue number3
DOIs
Publication statusPublished - 9 Feb 2024

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© 2024 Mounsey et al.

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