Geographical variation in relationships between parental body size and offspring phenostype at birth

SD Leary, C Osmond, H Lovel, D Campbell, J Eriksson, T Forrester, K Godfrey, JP Hill, M Jie, C Law, R Newby, S Robinson, cs Yajnik

Research output: Contribution to journalArticle (Academic Journal)peer-review

48 Citations (Scopus)

Abstract

Background. Size and body proportions at birth are partly determined by maternal body composition, but most studies of mother–baby relationships have only considered the effects of maternal height and weight on offspring birth weight, and few have examined the size of effects. Paternal size and body composition also play a role, primarily through the fetal genome, although few studies have investigated relationships with neonatal phenotype. Methods. Data from the UK, Finland, India, Sri Lanka, China, DR Congo, Nigeria and Jamaica were used to investigate the effects of maternal measures (derived at 30 weeks’ gestation, n=16,418), and also paternal size (n=3,733) on neonatal phenotype, for singleton, live-born, term births. Results. After accounting for variation in maternal size and shape across populations, differences in neonatal phenotype were markedly reduced. Mother–baby relationships were similar across populations, although some were stronger in developing countries. Maternal height was generally the strongest predictor of neonatal length, maternal head circumference of neonatal head and maternal skinfold thickness of neonatal skinfolds. Relationships with maternal arm muscle area were generally weak. Effects of paternal height and body mass index were weaker than the equivalent maternal measurements in most studies. Conclusions. Differences in maternal body composition account for a large part of the geographical variation in neonatal phenotype. The size of the effects of all maternal measures on neonatal phenotype suggests that nutrition at every stage of the mother's life cycle may influence fetal growth. Further research is needed into father–baby relationships and the genetic mechanisms that influence fetal growth.
Translated title of the contributionGeographical variation in relationships between parental body size and offspring phenostype at birth
Original languageEnglish
Pages (from-to)1066 - 1079
Number of pages14
JournalActa Obstetricia et Gynecologica Scandinavica
Volume85
DOIs
Publication statusPublished - 2006

Keywords

  • Size at birth;maternal body composition;maternal birth weight;paternal size;worldwide variation

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