Projects per year
Methods and analysis: A prospective longitudinal study is planned (start date: February, 2018; end date: March, 2023) on pregnant women that are being recruited in the first trimester and followed in subsequent trimesters and at the time of delivery (total 3-follow-ups). The study is being conducted in a hospital located in Bikaner district (66% rural population), Rajasthan, India. The estimated sample size is of 1000 mother-offspring pairs. Information on gynaecological and obstetric history, socioeconomic position, diet, physical activity, tobacco and alcohol consumption, depression, anthropometric measurements and blood samples is being collected for metabolic assays in each trimester using standardized methods. Mixed effects regression models will be used to assess the role of gestational weight in influencing metabolite levels in each trimester. The association of maternal levels of metabolites with foetal growth, offspring’s weight and body composition at birth will be investigated using regression modelling.
Ethics and dissemination: The study has been approved by the ethics committees of the Department of Anthropology, University of Delhi and Sardar Patel Medical College, Rajasthan. We are taking written informed consent after discussing the various aspects of the study with the participants in the local language.
Bibliographical note© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
- Birth cohort
- Metabolomics in Pregnancy
- Foetal growth
- Epidemiology and Developmental origin