Giving off mixed signals - distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour

MR Morgan, A Byron, MJ Humphries, MD Bass

Research output: Contribution to journalArticle (Academic Journal)

Abstract

The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, v3 and 51 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731-738, 2009
Translated title of the contributionGiving off mixed signals - distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour
Original languageEnglish
Pages (from-to)731 - 738
Number of pages8
JournalIUBMB Life
Volume61 (7)
Publication statusPublished - Jul 2009

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