Giving off mixed signals - distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour

MR Morgan; A Byron; MJ Humphries; MD Bass

Giving off mixed signals - distinct functions of α₅β₁ and α_Vβ₃ integrins in regulating cell behaviour

MR Morgan
, A Byron
, MJ Humphries
, MD Bass

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, v3 and 51 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731-738, 2009

Translated title of the contribution	Giving off mixed signals - distinct functions of α₅β₁ and α_Vβ₃ integrins in regulating cell behaviour
Original language	English
Pages (from-to)	731 - 738
Number of pages	8
Journal	IUBMB Life
Volume	61 (7)
Publication status	Published - Jul 2009

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title = "Giving off mixed signals - distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour",

abstract = "The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, v3 and 51 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. {\textcopyright} 2009 IUBMB IUBMB Life 61(7): 731-738, 2009",

author = "MR Morgan and A Byron and MJ Humphries and MD Bass",

year = "2009",

month = jul,

language = "English",

volume = "61 (7)",

pages = "731 -- 738",

journal = "IUBMB Life",

issn = "1521-6551",

publisher = "John Wiley and Sons Inc",

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TY - JOUR

T1 - Giving off mixed signals - distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour

AU - Morgan, MR

AU - Byron, A

AU - Humphries, MJ

AU - Bass, MD

PY - 2009/7

Y1 - 2009/7

N2 - The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, v3 and 51 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731-738, 2009

AB - The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, v3 and 51 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731-738, 2009

M3 - Article (Academic Journal)

SN - 1521-6551

VL - 61 (7)

SP - 731

EP - 738

JO - IUBMB Life

JF - IUBMB Life

ER -

Giving off mixed signals - distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour

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Giving off mixed signals - distinct functions of α₅β₁ and α_Vβ₃ integrins in regulating cell behaviour