Global health trials methodological research agenda: Results from a priority setting exercise

Anna Rosala-Hallas*, Aneel Bhangu, Jane Blazeby, Louise Bowman, Mike Clarke, Trudie Lang, Mona Nasser, Nandi Siegfried, Karla Soares-Weiser, Matt R. Sydes, Duolao Wang, Junhua Zhang, Paula R. Williamson

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
245 Downloads (Pure)

Abstract

Background
Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this research. These priorities however may not be reflected in the needs of similar research in low to middle income countries (LMICs) with different healthcare provision, resources and research infrastructure. The aim of the study was to identify the top priorities for methodological research in LMICs to inform further research and ultimately to improve clinical trials in these regions.

Methods
An online 2-round survey was conducted from Dec 2016 to April 2017 amongst researchers and methodologists working on trials in LMICs. The first round required participants to suggest between 3 and 6 topics which they felt were priorities for trials methodological research in LMICs. The second round invited participants to grade the importance of a compulsory list of topics suggested by 4 or more individuals, and an optional list of the remaining topics.

Findings
Rounds 1 and 2 were completed by 412 and 314 participants, respectively. A wide spread of years of experience, discipline, current country of residence, origin of trials training and area of involvement in trials was reported. The topics deemed most important for methodological research were: choosing appropriate outcomes to measure and training of research staff.

Conclusion
By presenting these top priorities we have the foundations of a global health trials methodological research agenda which we hope will foster future research in specific areas in order to increase and improve trials in LMICs.
Original languageEnglish
Article number48
Number of pages8
JournalTrials
Volume19
Issue number1
DOIs
Publication statusPublished - 5 Feb 2018

Structured keywords

  • Centre for Surgical Research

Keywords

  • Global health
  • Priority setting
  • Trials methodology

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    Rosala-Hallas, A., Bhangu, A., Blazeby, J., Bowman, L., Clarke, M., Lang, T., Nasser, M., Siegfried, N., Soares-Weiser, K., Sydes, M. R., Wang, D., Zhang, J., & Williamson, P. R. (2018). Global health trials methodological research agenda: Results from a priority setting exercise. Trials, 19(1), [48]. https://doi.org/10.1186/s13063-018-2440-y