GLUT1 protein expression correlates with unfavourable histologic category and high risk in patients with neuroblastic tumours

Pramila Ramani; Alison Headford; Margaret T May

doi:10.1007/s00428-012-1370-4

GLUT1 protein expression correlates with unfavourable histologic category and high risk in patients with neuroblastic tumours

Pramila Ramani
, Alison Headford
, Margaret T May

Research output: Contribution to journal › Article (Academic Journal) › peer-review

34 Citations (Scopus)

Abstract

GLUT1 is a hypoxia-induced gene that has many biologically important functions, and the overexpression of the GLUT1 protein correlates with poor prognosis in several adult cancers. The clinical significance of the GLUT1 protein in peripheral neuroblastic tumours (NTs) has not been comprehensively documented. In the present retrospective study, immunohistochemical analyses revealed the presence of GLUT1 in 44/96 (46 %) NTs. Membranous GLUT1 was present in neuroblasts of 44/87 neuroblastomas (NBs) and nodular ganglioneuroblastomas (nGNBs) but was absent in ganglion cells. The presence of GLUT1 was significantly increased in NBs and nGNBs compared with maturing ganglioneuromas and intermixed ganglioneuroblastomas (P

Original language	English
Journal	Virchows Archiv
DOIs	https://doi.org/10.1007/s00428-012-1370-4
Publication status	Published - 2013

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title = "GLUT1 protein expression correlates with unfavourable histologic category and high risk in patients with neuroblastic tumours",

abstract = "GLUT1 is a hypoxia-induced gene that has many biologically important functions, and the overexpression of the GLUT1 protein correlates with poor prognosis in several adult cancers. The clinical significance of the GLUT1 protein in peripheral neuroblastic tumours (NTs) has not been comprehensively documented. In the present retrospective study, immunohistochemical analyses revealed the presence of GLUT1 in 44/96 (46 \%) NTs. Membranous GLUT1 was present in neuroblasts of 44/87 neuroblastomas (NBs) and nodular ganglioneuroblastomas (nGNBs) but was absent in ganglion cells. The presence of GLUT1 was significantly increased in NBs and nGNBs compared with maturing ganglioneuromas and intermixed ganglioneuroblastomas (P ",

author = "Pramila Ramani and Alison Headford and May, \{Margaret T\}",

year = "2013",

doi = "10.1007/s00428-012-1370-4",

language = "English",

journal = "Virchows Archiv",

issn = "1432-2307",

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TY - JOUR

T1 - GLUT1 protein expression correlates with unfavourable histologic category and high risk in patients with neuroblastic tumours

AU - Ramani, Pramila

AU - Headford, Alison

AU - May, Margaret T

PY - 2013

Y1 - 2013

N2 - GLUT1 is a hypoxia-induced gene that has many biologically important functions, and the overexpression of the GLUT1 protein correlates with poor prognosis in several adult cancers. The clinical significance of the GLUT1 protein in peripheral neuroblastic tumours (NTs) has not been comprehensively documented. In the present retrospective study, immunohistochemical analyses revealed the presence of GLUT1 in 44/96 (46 %) NTs. Membranous GLUT1 was present in neuroblasts of 44/87 neuroblastomas (NBs) and nodular ganglioneuroblastomas (nGNBs) but was absent in ganglion cells. The presence of GLUT1 was significantly increased in NBs and nGNBs compared with maturing ganglioneuromas and intermixed ganglioneuroblastomas (P

AB - GLUT1 is a hypoxia-induced gene that has many biologically important functions, and the overexpression of the GLUT1 protein correlates with poor prognosis in several adult cancers. The clinical significance of the GLUT1 protein in peripheral neuroblastic tumours (NTs) has not been comprehensively documented. In the present retrospective study, immunohistochemical analyses revealed the presence of GLUT1 in 44/96 (46 %) NTs. Membranous GLUT1 was present in neuroblasts of 44/87 neuroblastomas (NBs) and nodular ganglioneuroblastomas (nGNBs) but was absent in ganglion cells. The presence of GLUT1 was significantly increased in NBs and nGNBs compared with maturing ganglioneuromas and intermixed ganglioneuroblastomas (P

U2 - 10.1007/s00428-012-1370-4

DO - 10.1007/s00428-012-1370-4

M3 - Article (Academic Journal)

C2 - 23307190

SN - 1432-2307

JO - Virchows Archiv

JF - Virchows Archiv

ER -

GLUT1 protein expression correlates with unfavourable histologic category and high risk in patients with neuroblastic tumours

Abstract

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