Electroactive biomaterials are fascinating for tissue engineering applications because of their ability to deliver electrical stimulation directly to cells, tissue, and organs. One particularly attractive conductive ﬁller for electroactive biomaterials is silver nanoparticles (AgNPs) because of their high conductivity, antibacterial activity, and ability to promote bone healing. However, production of AgNPs involves a toxic reducing agent which would inhibit biological scaffold performance. This work explores facile and green synthesis of AgNPs using extract of Cilembu sweet potato and studies the effect of baking and precursor concentrations (1, 10 and 100 mM) on AgNPs’ properties. Transmission electron microscope (TEM) results revealed that the smallest particle size of AgNPs (9.95 ± 3.69 nm) with nodular morphology was obtained by utilization of baked extract and ten mM AgNO 3 . Polycaprolactone (PCL)/AgNPs scaffolds exhibited several enhancements compared to PCL scaffolds. Compressive strength was six times greater (3.88 ± 0.42 MPa), more hydrophilic (contact angle of 76.8 ± 1.7 ◦ ), conductive (2.3 ± 0.5 × 10 −3 S/cm) and exhibited anti-bacterial properties against Staphylococcus aureus ATCC3658 (99.5% reduction of surviving bacteria). Despite the promising results, further investigation on biological assessment is required to obtain comprehensive study of this scaffold. This green synthesis approach together with the use of 3D printing opens a new route to manufacture AgNPs-based electroactive with improved anti-bacterial properties without utilization of any toxic organic solvents.
|Publication status||Published - 2 Apr 2021|
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Acknowledgments: The authors would like to acknowledge the funding provided by the Research, Community Service, and Innovation (P2MI) 2021 scheme from the Faculty of Mechanical and Aerospace Engineering, ITB. G.U.N.T. is grateful for the scholarship from The Indonesian Endowment Fund for Education (LPDP), The Indonesian Ministry of Finance 2016 (No. PRJ-1837/LPDP.3/2016). The Authors would also like to appreciate the Research Center for Nanoscience and Nanotechnology, Institut Teknologi Bandung, to utilize their characterization facilities and Ani Riani Kusmiati from School of Pharmacy, Institut Teknologi Bandung, for antibacterial testing.
Funding: This research was funded by the Research, Community Service, and Innovation (P2MI) 2021 scheme from the Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung (ITB).
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