Guidelines for tunneling in enzymes

CC Moser, JLR Anderson, PL Dutton

Research output: Contribution to journalArticle (Academic Journal)peer-review

82 Citations (Scopus)

Abstract

Here we extend the engineering descriptions of simple, single-electron-tunneling chains common in oxidoreductases to quantify sequential oxidation–reduction rates of two-or-more electron cofactors and substrates. We identify when nicotinamides may be vulnerable to radical mediated oxidation–reduction and merge electron-tunneling expressions with the chemical rate expressions of Eyring. The work provides guidelines for the construction of new artificial oxidoreductases inspired by Nature but adopting independent design and redox engineering.
Translated title of the contributionGuidelines for tunneling in enzymes
Original languageEnglish
Pages (from-to)1573 - 1586
Number of pages14
JournalBiochimica et Biophysica Acta (BBA) - Bioenergetics
Volume1797 (9)
DOIs
Publication statusPublished - Sep 2010

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