Abstract
Here we report the H-1, C-13 and N-15 resonance assignments of free Bcl-x(L) and of Bcl-x(L) in complex with an azobenzene-modified peptide derived from the BH3 domain of the pro-apoptotic Bak. The spectra suggest predominantly folded proteins; chemical shift difference analysis provides a detailed view of the reorganization occurring on peptide binding.
Original language | English |
---|---|
Article number | 10.1007/s12104-012-9378-x |
Pages (from-to) | 187-191 |
Number of pages | 5 |
Journal | Biomolecular NMR Assignments |
Volume | 7 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 2013 |
Keywords
- Bcl-x(L)
- Bcl-2 family
- Photonano-switches
- Azobenzene
- BCL-X-L
- PROTEIN
- APOPTOSIS