TY - JOUR
T1 - Habitual coffee consumption and cognitive function
T2 - a Mendelian randomization meta-analysis in up to 415,530 participants
AU - Zhou, Ang
AU - Taylor, Amy E.
AU - Karhunen, Ville
AU - Zhan, Yiqiang
AU - Rovio, Suvi P.
AU - Lahti, Jari
AU - Sjögren, Per
AU - Byberg, Liisa
AU - Lyall, Donald M.
AU - Auvinen, Juha
AU - Lehtimäki, Terho
AU - Kähönen, Mika
AU - Hutri-Kähönen, Nina
AU - Perälä, Mia Maria
AU - Michaëlsson, Karl
AU - Mahajan, Anubha
AU - Lind, Lars
AU - Power, Chris
AU - Eriksson, Johan G.
AU - Raitakari, Olli T.
AU - Hägg, Sara
AU - Pedersen, Nancy L.
AU - Veijola, Juha
AU - Järvelin, Marjo Riitta
AU - Munafò, Marcus R.
AU - Ingelsson, Erik
AU - Llewellyn, David J.
AU - Hyppönen, Elina
PY - 2018/5/14
Y1 - 2018/5/14
N2 - Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid-to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β =-0.0007, 95% C.I.-0.009 to 0.008, P = 0.87; β =-0.001, 95% C.I.-0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.
AB - Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid-to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β =-0.0007, 95% C.I.-0.009 to 0.008, P = 0.87; β =-0.001, 95% C.I.-0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.
UR - http://www.scopus.com/inward/record.url?scp=85046999462&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-25919-2
DO - 10.1038/s41598-018-25919-2
M3 - Article (Academic Journal)
C2 - 29760501
AN - SCOPUS:85046999462
VL - 8
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 7526
ER -