Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi's disease)

U Mahadeva, T Allport, B Bain, W K Chan

Research output: Contribution to journalArticle (Academic Journal)peer-review

46 Citations (Scopus)


A young boy presented with a rash, fever, and cervical lymphadenopathy, originally thought to be caused by tuberculosis. A lymph node biopsy showed the features of Kikuchi's disease, with necrosis and histiocytic infiltration without neutrophils. No evidence of tuberculosis was found on staining, culture, or the polymerase chain reaction. Bone marrow biopsy revealed prominent haemophagocytosis, and a diagnosis of haemophagocytic syndrome was reached. The aetiology of haemophagocytic syndrome, and its association with Kikuchi's lymphadenitis, is discussed.

Original languageEnglish
Pages (from-to)636-8
Number of pages3
JournalJournal of Clinical Pathology
Issue number8
Publication statusPublished - Aug 2000


  • Bone Marrow/pathology
  • Child, Preschool
  • Follow-Up Studies
  • Histiocytic Necrotizing Lymphadenitis/complications
  • Histiocytosis, Non-Langerhans-Cell/complications
  • Humans
  • Lymph Nodes/pathology
  • Male


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