Abstract
This chapter reviews the pathogenesis of Haemophilus influenzae type b (Hib) meningitis, a multistep process that begins with: (i) colonization of the nasopharynx; (ii) subsequent invasion into the blood, which leads to haematogenous dissemination; (iii) bacterial penetration of the blood-cerebrospinal fluid barrier/blood-brain barrier and entry into the subarachnoid space; which leads to (iv) a compartmentalized host inflammatory response. A newborn rat model for Hib meningitis is proposed, which is based on current knowledge of bacterial virulence factors and host cell receptor recognition of these ligands.
Original language | English |
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Title of host publication | Meningitis: cellular and molecular basis |
Publisher | CABI Publishing |
Pages | 91-103 |
ISBN (Print) | 9781780641621 |
DOIs | |
Publication status | Published - Aug 2013 |