Haemophilus influenzae meningitis

Darryl J Hill, M Christodoulides

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

75 Citations (Scopus)

Abstract

This chapter reviews the pathogenesis of Haemophilus influenzae type b (Hib) meningitis, a multistep process that begins with: (i) colonization of the nasopharynx; (ii) subsequent invasion into the blood, which leads to haematogenous dissemination; (iii) bacterial penetration of the blood-cerebrospinal fluid barrier/blood-brain barrier and entry into the subarachnoid space; which leads to (iv) a compartmentalized host inflammatory response. A newborn rat model for Hib meningitis is proposed, which is based on current knowledge of bacterial virulence factors and host cell receptor recognition of these ligands.
Original languageEnglish
Title of host publicationMeningitis: cellular and molecular basis
PublisherCABI Publishing
Pages91-103
ISBN (Print)9781780641621
DOIs
Publication statusPublished - Aug 2013

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