Consistent evidence suggests inverse and independent associations between handgrip strength (HGS) and cardiovascular outcomes. However, whether HGS is specifically related to future risk of atrial fibrillation (AF) is uncertain. We sought to assess the prospective association between HGS and risk of AF. Handgrip strength was assessed using a hand dynamometer in a general population-based cohort of 827 men and women aged 61-74 years with no history of AF at study entry. Abso-lute values of HGS were allometrically scaled to account for the effect of body weight (handgrip strength/body weight2/3) and to normalize the data. Hazard ratios (HRs) with 95% confidence inter-vals (CIs) were estimated for AF. During a median (interquartile range) follow-up of 15.7 (9.5-18.8) years, 265 AF cases were recorded. The HR (95% CI) for AF per 1 standard deviation in-crease in normalized HGS in age- and sex-adjusted analysis was 0.73 (0.61-0.86). The association remained similar in analyses adjusted for several established and emerging risk factors 0.77 (0.64-0.92). The corresponding adjusted HRs (95% CIs) were 0.53 (0.39-0.73) and 0.60 (0.44-0.83), re-spectively, when comparing the top versus bottom tertiles of normalized HG. In conclusion, nor-malized HGS is inversely associated with the future risk of AF in the general population.