Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain

Nina Rieckmann; Konrad Neumann; Sarah Feger; Paolo Ibes; Adriane Napp; Daniel Preuß; Henryk Dreger; Gudrun Feuchtner; Fabian Plank; Vojtěch Suchánek; Josef Veselka; Thomas Engstrøm; Klaus F Kofoed; Stephen Schröder; Thomas Zelesny; Matthias Gutberlet; Michael Woinke; Pál Maurovich-Horvat; Béla Merkely; Patrick Donnelly; Peter Ball; Jonathan D Dodd; Mark Hensey; Bruno Loi; Luca Saba; Marco Francone; Massimo Mancone; Marina Berzina; Andrejs Erglis; Audrone Vaitiekiene; Laura Zajanckauskiene; Tomasz Harań; Malgorzata Ilnicka Suckiel; Rita Faria; Vasco Gama-Ribeiro; Imre Benedek; Ioana Rodean; Filip Adjić; Nada Čemerlić Adjić; José Rodriguez-Palomares; Bruno Garcia Del Blanco; Katriona Brooksbank; Damien Collison; Gershan Davis; Erica Thwaite; Juhani Knuuti; Antti Saraste; Cezary Kępka; Mariusz Kruk; Theodora Benedek; Mihaela Ratiu; Aleksandar N Neskovic; Radosav Vidakovic; Ignacio Diez; Iñigo Lecumberri; Michael Fisher; Balasz Ruzsics; William Hollingworth; Iñaki Gutiérrez-Ibarluzea; Marc Dewey; Jacqueline Müller-Nordhorn

doi:10.1186/s12955-020-01312-4

Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain

Nina Rieckmann, Konrad Neumann, Sarah Feger, Paolo Ibes, Adriane Napp, Daniel Preuß, Henryk Dreger, Gudrun Feuchtner, Fabian Plank, Vojtěch Suchánek, Josef Veselka, Thomas Engstrøm, Klaus F Kofoed, Stephen Schröder, Thomas Zelesny, Matthias Gutberlet, Michael Woinke, Pál Maurovich-Horvat, Béla Merkely, Patrick DonnellyPeter Ball, Jonathan D Dodd, Mark Hensey, Bruno Loi, Luca Saba, Marco Francone, Massimo Mancone, Marina Berzina, Andrejs Erglis, Audrone Vaitiekiene, Laura Zajanckauskiene, Tomasz Harań, Malgorzata Ilnicka Suckiel, Rita Faria, Vasco Gama-Ribeiro, Imre Benedek, Ioana Rodean, Filip Adjić, Nada Čemerlić Adjić, José Rodriguez-Palomares, Bruno Garcia Del Blanco, Katriona Brooksbank, Damien Collison, Gershan Davis, Erica Thwaite, Juhani Knuuti, Antti Saraste, Cezary Kępka, Mariusz Kruk, Theodora Benedek, Mihaela Ratiu, Aleksandar N Neskovic, Radosav Vidakovic, Ignacio Diez, Iñigo Lecumberri, Michael Fisher, Balasz Ruzsics, William Hollingworth, Iñaki Gutiérrez-Ibarluzea, Marc Dewey, Jacqueline Müller-Nordhorn

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

Abstract

BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.

METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.

RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.

CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.

TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.

Original language	English
Pages (from-to)	140
Journal	Health and Quality of Life Outcomes
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12955-020-01312-4
Publication status	Published - 14 May 2020

Access to Document

10.1186/s12955-020-01312-4

Handle.net

Persistent link

Cite this

Rieckmann, N., Neumann, K., Feger, S., Ibes, P., Napp, A., Preuß, D., Dreger, H., Feuchtner, G., Plank, F., Suchánek, V., Veselka, J., Engstrøm, T., Kofoed, K. F., Schröder, S., Zelesny, T., Gutberlet, M., Woinke, M., Maurovich-Horvat, P., Merkely, B., ... Müller-Nordhorn, J. (2020). Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain. Health and Quality of Life Outcomes, 18(1), 140. https://doi.org/10.1186/s12955-020-01312-4

@article{b113473923684f1bbb42d0686ab19a69,

title = "Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain",

abstract = "BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.",

author = "Nina Rieckmann and Konrad Neumann and Sarah Feger and Paolo Ibes and Adriane Napp and Daniel Preu{\ss} and Henryk Dreger and Gudrun Feuchtner and Fabian Plank and Vojt{\v e}ch Such{\'a}nek and Josef Veselka and Thomas Engstr{\o}m and Kofoed, {Klaus F} and Stephen Schr{\"o}der and Thomas Zelesny and Matthias Gutberlet and Michael Woinke and P{\'a}l Maurovich-Horvat and B{\'e}la Merkely and Patrick Donnelly and Peter Ball and Dodd, {Jonathan D} and Mark Hensey and Bruno Loi and Luca Saba and Marco Francone and Massimo Mancone and Marina Berzina and Andrejs Erglis and Audrone Vaitiekiene and Laura Zajanckauskiene and Tomasz Hara{\'n} and Suckiel, {Malgorzata Ilnicka} and Rita Faria and Vasco Gama-Ribeiro and Imre Benedek and Ioana Rodean and Filip Adji{\'c} and {{\v C}emerli{\'c} Adji{\'c}}, Nada and Jos{\'e} Rodriguez-Palomares and {Garcia Del Blanco}, Bruno and Katriona Brooksbank and Damien Collison and Gershan Davis and Erica Thwaite and Juhani Knuuti and Antti Saraste and Cezary K{\c e}pka and Mariusz Kruk and Theodora Benedek and Mihaela Ratiu and Neskovic, {Aleksandar N} and Radosav Vidakovic and Ignacio Diez and I{\~n}igo Lecumberri and Michael Fisher and Balasz Ruzsics and William Hollingworth and I{\~n}aki Guti{\'e}rrez-Ibarluzea and Marc Dewey and Jacqueline M{\"u}ller-Nordhorn",

year = "2020",

month = may,

day = "14",

doi = "10.1186/s12955-020-01312-4",

language = "English",

volume = "18",

pages = "140",

journal = "Health and Quality of Life Outcomes",

issn = "1477-7525",

publisher = "BioMed Central",

number = "1",

}

Rieckmann, N, Neumann, K, Feger, S, Ibes, P, Napp, A, Preuß, D, Dreger, H, Feuchtner, G, Plank, F, Suchánek, V, Veselka, J, Engstrøm, T, Kofoed, KF, Schröder, S, Zelesny, T, Gutberlet, M, Woinke, M, Maurovich-Horvat, P, Merkely, B, Donnelly, P, Ball, P, Dodd, JD, Hensey, M, Loi, B, Saba, L, Francone, M, Mancone, M, Berzina, M, Erglis, A, Vaitiekiene, A, Zajanckauskiene, L, Harań, T, Suckiel, MI, Faria, R, Gama-Ribeiro, V, Benedek, I, Rodean, I, Adjić, F, Čemerlić Adjić, N, Rodriguez-Palomares, J, Garcia Del Blanco, B, Brooksbank, K, Collison, D, Davis, G, Thwaite, E, Knuuti, J, Saraste, A, Kępka, C, Kruk, M, Benedek, T, Ratiu, M, Neskovic, AN, Vidakovic, R, Diez, I, Lecumberri, I, Fisher, M, Ruzsics, B, Hollingworth, W, Gutiérrez-Ibarluzea, I, Dewey, M & Müller-Nordhorn, J 2020, 'Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain', Health and Quality of Life Outcomes, vol. 18, no. 1, pp. 140. https://doi.org/10.1186/s12955-020-01312-4

TY - JOUR

T1 - Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain

AU - Rieckmann, Nina

AU - Neumann, Konrad

AU - Feger, Sarah

AU - Ibes, Paolo

AU - Napp, Adriane

AU - Preuß, Daniel

AU - Dreger, Henryk

AU - Feuchtner, Gudrun

AU - Plank, Fabian

AU - Suchánek, Vojtěch

AU - Veselka, Josef

AU - Engstrøm, Thomas

AU - Kofoed, Klaus F

AU - Schröder, Stephen

AU - Zelesny, Thomas

AU - Gutberlet, Matthias

AU - Woinke, Michael

AU - Maurovich-Horvat, Pál

AU - Merkely, Béla

AU - Donnelly, Patrick

AU - Ball, Peter

AU - Dodd, Jonathan D

AU - Hensey, Mark

AU - Loi, Bruno

AU - Saba, Luca

AU - Francone, Marco

AU - Mancone, Massimo

AU - Berzina, Marina

AU - Erglis, Andrejs

AU - Vaitiekiene, Audrone

AU - Zajanckauskiene, Laura

AU - Harań, Tomasz

AU - Suckiel, Malgorzata Ilnicka

AU - Faria, Rita

AU - Gama-Ribeiro, Vasco

AU - Benedek, Imre

AU - Rodean, Ioana

AU - Adjić, Filip

AU - Čemerlić Adjić, Nada

AU - Rodriguez-Palomares, José

AU - Garcia Del Blanco, Bruno

AU - Brooksbank, Katriona

AU - Collison, Damien

AU - Davis, Gershan

AU - Thwaite, Erica

AU - Knuuti, Juhani

AU - Saraste, Antti

AU - Kępka, Cezary

AU - Kruk, Mariusz

AU - Benedek, Theodora

AU - Ratiu, Mihaela

AU - Neskovic, Aleksandar N

AU - Vidakovic, Radosav

AU - Diez, Ignacio

AU - Lecumberri, Iñigo

AU - Fisher, Michael

AU - Ruzsics, Balasz

AU - Hollingworth, William

AU - Gutiérrez-Ibarluzea, Iñaki

AU - Dewey, Marc

AU - Müller-Nordhorn, Jacqueline

PY - 2020/5/14

Y1 - 2020/5/14

N2 - BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.

AB - BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.

U2 - 10.1186/s12955-020-01312-4

DO - 10.1186/s12955-020-01312-4

M3 - Article (Academic Journal)

C2 - 32410687

SN - 1477-7525

VL - 18

SP - 140

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

IS - 1

ER -

Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain

Abstract

Access to Document

Handle.net

Fingerprint

Cite this