Heart rate and suicide: findings from two cohorts of 533 000 Taiwanese and 75 000 Norwegian adults

S-S Chang; J H Bjørngaard; M K Tsai; O Bjerkeset; C P Wen; Paul S F Yip; C K Tsao; D Gunnell

doi:10.1111/acps.12513

Heart rate and suicide: findings from two cohorts of 533 000 Taiwanese and 75 000 Norwegian adults

S-S Chang, J H Bjørngaard, M K Tsai, O Bjerkeset, C P Wen, Paul S F Yip, C K Tsao, D Gunnell

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the association of resting heart rate with suicide in two large cohorts.

METHOD: The MJ cohort (Taiwan) included 532 932 adults from a health check-up programme (1994-2008). The HUNT cohort (Norway) included 74 977 adults in the Nord-Trøndelag County study (1984-1986), followed up to 2004. In both cohorts heart rate was measured at baseline, and suicide was ascertained through linkage to cause-of-death registers. Risk of suicide was estimated using Cox proportional hazards models.

RESULTS: There were 569 and 188 suicides (average follow-up period of 8.1 and 16.9 years) in the MJ and HUNT cohorts respectively. Sex- and age-adjusted hazard ratio for every 10 beat increase in heart rate per minute was 1.08 (95% Confidence Interval 1.00-1.16) and 1.24 (1.12-1.38) in the MJ and HUNT cohorts, respectively. In the MJ cohort this association was confined to individuals with a history of heart diseases vs. those without such a history (P for interaction = 0.008). In the HUNT cohort the association did not differ by history of heart diseases and was robust to adjustment for health-related life style, medication use, and symptoms of anxiety and depression.

CONCLUSION: Elevated resting heart rate may be a marker of increased suicide risk.

Original language	English
Pages (from-to)	277-88
Number of pages	12
Journal	Acta Psychiatrica Scandinavica
Volume	133
Issue number	4
Early online date	22 Oct 2015
DOIs	https://doi.org/10.1111/acps.12513
Publication status	Published - 16 Mar 2016

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title = "Heart rate and suicide: findings from two cohorts of 533 000 Taiwanese and 75 000 Norwegian adults",

abstract = "OBJECTIVE: To investigate the association of resting heart rate with suicide in two large cohorts.METHOD: The MJ cohort (Taiwan) included 532 932 adults from a health check-up programme (1994-2008). The HUNT cohort (Norway) included 74 977 adults in the Nord-Tr{\o}ndelag County study (1984-1986), followed up to 2004. In both cohorts heart rate was measured at baseline, and suicide was ascertained through linkage to cause-of-death registers. Risk of suicide was estimated using Cox proportional hazards models.RESULTS: There were 569 and 188 suicides (average follow-up period of 8.1 and 16.9 years) in the MJ and HUNT cohorts respectively. Sex- and age-adjusted hazard ratio for every 10 beat increase in heart rate per minute was 1.08 (95% Confidence Interval 1.00-1.16) and 1.24 (1.12-1.38) in the MJ and HUNT cohorts, respectively. In the MJ cohort this association was confined to individuals with a history of heart diseases vs. those without such a history (P for interaction = 0.008). In the HUNT cohort the association did not differ by history of heart diseases and was robust to adjustment for health-related life style, medication use, and symptoms of anxiety and depression.CONCLUSION: Elevated resting heart rate may be a marker of increased suicide risk.",

author = "S-S Chang and Bj{\o}rngaard, {J H} and Tsai, {M K} and O Bjerkeset and Wen, {C P} and Yip, {Paul S F} and Tsao, {C K} and D Gunnell",

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language = "English",

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TY - JOUR

T1 - Heart rate and suicide

T2 - findings from two cohorts of 533 000 Taiwanese and 75 000 Norwegian adults

AU - Chang, S-S

AU - Bjørngaard, J H

AU - Tsai, M K

AU - Bjerkeset, O

AU - Wen, C P

AU - Yip, Paul S F

AU - Tsao, C K

AU - Gunnell, D

PY - 2016/3/16

Y1 - 2016/3/16

N2 - OBJECTIVE: To investigate the association of resting heart rate with suicide in two large cohorts.METHOD: The MJ cohort (Taiwan) included 532 932 adults from a health check-up programme (1994-2008). The HUNT cohort (Norway) included 74 977 adults in the Nord-Trøndelag County study (1984-1986), followed up to 2004. In both cohorts heart rate was measured at baseline, and suicide was ascertained through linkage to cause-of-death registers. Risk of suicide was estimated using Cox proportional hazards models.RESULTS: There were 569 and 188 suicides (average follow-up period of 8.1 and 16.9 years) in the MJ and HUNT cohorts respectively. Sex- and age-adjusted hazard ratio for every 10 beat increase in heart rate per minute was 1.08 (95% Confidence Interval 1.00-1.16) and 1.24 (1.12-1.38) in the MJ and HUNT cohorts, respectively. In the MJ cohort this association was confined to individuals with a history of heart diseases vs. those without such a history (P for interaction = 0.008). In the HUNT cohort the association did not differ by history of heart diseases and was robust to adjustment for health-related life style, medication use, and symptoms of anxiety and depression.CONCLUSION: Elevated resting heart rate may be a marker of increased suicide risk.

AB - OBJECTIVE: To investigate the association of resting heart rate with suicide in two large cohorts.METHOD: The MJ cohort (Taiwan) included 532 932 adults from a health check-up programme (1994-2008). The HUNT cohort (Norway) included 74 977 adults in the Nord-Trøndelag County study (1984-1986), followed up to 2004. In both cohorts heart rate was measured at baseline, and suicide was ascertained through linkage to cause-of-death registers. Risk of suicide was estimated using Cox proportional hazards models.RESULTS: There were 569 and 188 suicides (average follow-up period of 8.1 and 16.9 years) in the MJ and HUNT cohorts respectively. Sex- and age-adjusted hazard ratio for every 10 beat increase in heart rate per minute was 1.08 (95% Confidence Interval 1.00-1.16) and 1.24 (1.12-1.38) in the MJ and HUNT cohorts, respectively. In the MJ cohort this association was confined to individuals with a history of heart diseases vs. those without such a history (P for interaction = 0.008). In the HUNT cohort the association did not differ by history of heart diseases and was robust to adjustment for health-related life style, medication use, and symptoms of anxiety and depression.CONCLUSION: Elevated resting heart rate may be a marker of increased suicide risk.

U2 - 10.1111/acps.12513

DO - 10.1111/acps.12513

M3 - Article (Academic Journal)

C2 - 26493376

SN - 0001-690X

VL - 133

SP - 277

EP - 288

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 4

ER -

Heart rate and suicide: findings from two cohorts of 533 000 Taiwanese and 75 000 Norwegian adults

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