TY - JOUR
T1 - Heavier smoking may lead to a relative increase in waist circumference
T2 - evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium
AU - Morris, Richard W
AU - Taylor, Amy E
AU - Fluharty, Meg E
AU - Bjørngaard, Johan H
AU - Åsvold, Bjørn Olav
AU - Elvestad Gabrielsen, Maiken
AU - Campbell, Archie
AU - Marioni, Riccardo
AU - Kumari, Meena
AU - Korhonen, Tellervo
AU - Männistö, Satu
AU - Marques-Vidal, Pedro
AU - Kaakinen, Marika
AU - Cavadino, Alana
AU - Postmus, Iris
AU - Husemoen, Lise Lotte N
AU - Skaaby, Tea
AU - Ahluwalia, Tarun Veer Singh
AU - Treur, Jorien L
AU - Willemsen, Gonneke
AU - Dale, Caroline
AU - Wannamethee, S Goya
AU - Lahti, Jari
AU - Palotie, Aarno
AU - Räikkönen, Katri
AU - McConnachie, Alex
AU - Padmanabhan, Sandosh
AU - Wong, Andrew
AU - Dalgård, Christine
AU - Paternoster, Lavinia
AU - Ben-Shlomo, Yoav
AU - Tyrrell, Jessica
AU - Horwood, John
AU - Fergusson, David M
AU - Kennedy, Martin A
AU - Nohr, Ellen A
AU - Christiansen, Lene
AU - Kyvik, Kirsten Ohm
AU - Kuh, Diana
AU - Watt, Graham
AU - Eriksson, Johan G
AU - Whincup, Peter H
AU - Vink, Jacqueline M
AU - Boomsma, Dorret I
AU - Davey Smith, George
AU - Lawlor, Debbie
AU - Linneberg, Allan
AU - Ford, Ian
AU - Jukema, J Wouter
AU - Power, Chris
AU - Hyppönen, Elina
AU - Jarvelin, Marjo-Riitta
AU - Preisig, Martin
AU - Borodulin, Katja
AU - Kaprio, Jaakko
AU - Kivimaki, Mika
AU - Smith, Blair H
AU - Hayward, Caroline
AU - Romundstad, Pål R
AU - Sorensen, Thorkild
AU - Munafò, Marcus R
AU - Sattar, Naveed
N1 - Date of Acceptance: 21/07/2015
PY - 2015/8/11
Y1 - 2015/8/11
N2 - Objectives To investigate, using a Mendelian
randomisation approach, whether heavier smoking is associated with a range of
regional adiposity phenotypes, in particular those related to abdominal
adiposity.
Design Mendelian randomisation meta-analyses
using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene
region) as a proxy for smoking heaviness, of the associations of smoking
heaviness with a range of adiposity phenotypes.
Participants 148 731 current, former and
never-smokers of European ancestry aged ≥16 years from 29 studies in the
consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).
Primary outcome measures Waist and hip
circumferences, and waist-hip ratio.
Results The data included up to 66 809
never-smokers, 43 009 former smokers and 38 913 current daily cigarette
smokers. Among current smokers, for each extra minor allele, the geometric mean
was lower for waist circumference by −0.40% (95% CI −0.57% to −0.22%), with
effects on hip circumference, waist-hip ratio and body mass index (BMI) being
−0.31% (95% CI −0.42% to −0.19), −0.08% (−0.19% to 0.03%) and −0.74% (−0.96% to
−0.51%), respectively. In contrast, among never-smokers, these effects were
higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (−0.01% to
0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three
central adiposity measures for BMI, the effects among current smokers changed
direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference,
0.02% (−0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for
waist-hip ratio, for each extra minor allele.
Conclusions For a given BMI, a gene variant
associated with increased cigarette consumption was associated with increased
waist circumference. Smoking in an effort to control weight may lead to
accumulation of central adiposity
AB - Objectives To investigate, using a Mendelian
randomisation approach, whether heavier smoking is associated with a range of
regional adiposity phenotypes, in particular those related to abdominal
adiposity.
Design Mendelian randomisation meta-analyses
using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene
region) as a proxy for smoking heaviness, of the associations of smoking
heaviness with a range of adiposity phenotypes.
Participants 148 731 current, former and
never-smokers of European ancestry aged ≥16 years from 29 studies in the
consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).
Primary outcome measures Waist and hip
circumferences, and waist-hip ratio.
Results The data included up to 66 809
never-smokers, 43 009 former smokers and 38 913 current daily cigarette
smokers. Among current smokers, for each extra minor allele, the geometric mean
was lower for waist circumference by −0.40% (95% CI −0.57% to −0.22%), with
effects on hip circumference, waist-hip ratio and body mass index (BMI) being
−0.31% (95% CI −0.42% to −0.19), −0.08% (−0.19% to 0.03%) and −0.74% (−0.96% to
−0.51%), respectively. In contrast, among never-smokers, these effects were
higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (−0.01% to
0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three
central adiposity measures for BMI, the effects among current smokers changed
direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference,
0.02% (−0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for
waist-hip ratio, for each extra minor allele.
Conclusions For a given BMI, a gene variant
associated with increased cigarette consumption was associated with increased
waist circumference. Smoking in an effort to control weight may lead to
accumulation of central adiposity
U2 - 10.1136/bmjopen-2015-008808
DO - 10.1136/bmjopen-2015-008808
M3 - Article (Academic Journal)
C2 - 26264275
SN - 2044-6055
VL - 5
JO - BMJ Open
JF - BMJ Open
IS - 8
M1 - e008808
ER -