Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae

Qiu E Yang, Siham Rajab Agouri, Jonathan Mark Tyrrell, Timothy Rutland Walsh

Research output: Contribution to journalArticle (Academic Journal)peer-review

34 Citations (Scopus)


The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Issue number5
Publication statusPublished - May 2018

Bibliographical note

Copyright © 2018 Yang et al.


  • Anti-Bacterial Agents/pharmacology
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Enterobacteriaceae/drug effects
  • Metals, Heavy/pharmacology
  • Microbial Sensitivity Tests
  • Plasmids/genetics
  • beta-Lactamases/genetics


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