Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae

Qiu E Yang, Siham Rajab Agouri, Jonathan Mark Tyrrell, Timothy Rutland Walsh

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number5
DOIs
Publication statusPublished - May 2018

Bibliographical note

Copyright © 2018 Yang et al.

Keywords

  • Anti-Bacterial Agents/pharmacology
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Enterobacteriaceae/drug effects
  • Metals, Heavy/pharmacology
  • Microbial Sensitivity Tests
  • Plasmids/genetics
  • beta-Lactamases/genetics

Fingerprint Dive into the research topics of 'Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae'. Together they form a unique fingerprint.

Cite this