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Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis

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Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis. / Zuccolo, L; Harris, RJ; Gunnell, DJ; Oliver, S; Lane, JA; Davis, MJ; Donovan, JL; Neal, D; Hamdy, F; Beynon, R; Savovic, J; Martin, RM.

In: Cancer Epidemiology, Biomarkers and Prevention, Vol. 17(9), 09.2008, p. 2325 - 2336.

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Zuccolo, L, Harris, RJ, Gunnell, DJ, Oliver, S, Lane, JA, Davis, MJ, Donovan, JL, Neal, D, Hamdy, F, Beynon, R, Savovic, J & Martin, RM 2008, 'Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis', Cancer Epidemiology, Biomarkers and Prevention, vol. 17(9), pp. 2325 - 2336. https://doi.org/10.1158/1055-9965.EPI-08-0342

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Vancouver

Zuccolo L, Harris RJ, Gunnell DJ, Oliver S, Lane JA, Davis MJ et al. Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis. Cancer Epidemiology, Biomarkers and Prevention. 2008 Sep;17(9):2325 - 2336. https://doi.org/10.1158/1055-9965.EPI-08-0342

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Zuccolo, L ; Harris, RJ ; Gunnell, DJ ; Oliver, S ; Lane, JA ; Davis, MJ ; Donovan, JL ; Neal, D ; Hamdy, F ; Beynon, R ; Savovic, J ; Martin, RM. / Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis. In: Cancer Epidemiology, Biomarkers and Prevention. 2008 ; Vol. 17(9). pp. 2325 - 2336.

Bibtex

@article{6c457c7cf6d7461f855c3e183c689d29,
title = "Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis",
abstract = "Background: Height, a marker of childhood environmental exposures, is positively associated with prostate cancer risk, perhaps through the insulin-like growth factor system. We investigated the relationship of prostate cancer with height and its components (leg and trunk length) in a nested case-control study and with height in a dose-response meta-analysis. Methods: We nested a case-control study within a population-based randomized controlled trial evaluating treatments for localized prostate cancer in British men ages 50 to 69 years, including 1,357 cases detected through prostate-specific antigen testing and 7,990 controls (matched on age, general practice, assessment date). Nine bibliographic databases were searched systematically for studies on the heightprostate cancer association that were pooled in a meta-analysis. Results: Based on the nested case-control, the odds ratio (OR) of prostate-specific antigen–detected prostate cancer per 10 cm increase in height was 1.06 [95{\%} confidence interval (95{\%} CI): 0.97-1.16; ptrend = 0.2]. There was stronger evidence of an association of height with high-grade prostate cancer (OR: 1.23; 95{\%} CI: 1.06- 1.43), mainly due to the leg component, but not with low-grade disease (OR: 0.99; 95{\%} CI: 0.90-1.10). In general, associations with leg or trunk length were similar. A meta-analysis of 58 studies found evidence that height is positively associated with prostate cancer (random-effects OR per 10 cm: 1.06; 95{\%} CI: 1.03-1.09), with a stronger effect for prospective studies of more advanced/aggressive cancers (random-effects OR: 1.12; 95{\%} CI: 1.05-1.19). Conclusion: These data indicate a limited role for childhood environmental exposures—as indexed by adult height—on prostate cancer incidence, while suggesting a greater role for progression, through mechanisms requiring further investigation.",
author = "L Zuccolo and RJ Harris and DJ Gunnell and S Oliver and JA Lane and MJ Davis and JL Donovan and D Neal and F Hamdy and R Beynon and J Savovic and RM Martin",
year = "2008",
month = "9",
doi = "10.1158/1055-9965.EPI-08-0342",
language = "English",
volume = "17(9)",
pages = "2325 -- 2336",
journal = "Cancer Epidemiology, Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis

AU - Zuccolo, L

AU - Harris, RJ

AU - Gunnell, DJ

AU - Oliver, S

AU - Lane, JA

AU - Davis, MJ

AU - Donovan, JL

AU - Neal, D

AU - Hamdy, F

AU - Beynon, R

AU - Savovic, J

AU - Martin, RM

PY - 2008/9

Y1 - 2008/9

N2 - Background: Height, a marker of childhood environmental exposures, is positively associated with prostate cancer risk, perhaps through the insulin-like growth factor system. We investigated the relationship of prostate cancer with height and its components (leg and trunk length) in a nested case-control study and with height in a dose-response meta-analysis. Methods: We nested a case-control study within a population-based randomized controlled trial evaluating treatments for localized prostate cancer in British men ages 50 to 69 years, including 1,357 cases detected through prostate-specific antigen testing and 7,990 controls (matched on age, general practice, assessment date). Nine bibliographic databases were searched systematically for studies on the heightprostate cancer association that were pooled in a meta-analysis. Results: Based on the nested case-control, the odds ratio (OR) of prostate-specific antigen–detected prostate cancer per 10 cm increase in height was 1.06 [95% confidence interval (95% CI): 0.97-1.16; ptrend = 0.2]. There was stronger evidence of an association of height with high-grade prostate cancer (OR: 1.23; 95% CI: 1.06- 1.43), mainly due to the leg component, but not with low-grade disease (OR: 0.99; 95% CI: 0.90-1.10). In general, associations with leg or trunk length were similar. A meta-analysis of 58 studies found evidence that height is positively associated with prostate cancer (random-effects OR per 10 cm: 1.06; 95% CI: 1.03-1.09), with a stronger effect for prospective studies of more advanced/aggressive cancers (random-effects OR: 1.12; 95% CI: 1.05-1.19). Conclusion: These data indicate a limited role for childhood environmental exposures—as indexed by adult height—on prostate cancer incidence, while suggesting a greater role for progression, through mechanisms requiring further investigation.

AB - Background: Height, a marker of childhood environmental exposures, is positively associated with prostate cancer risk, perhaps through the insulin-like growth factor system. We investigated the relationship of prostate cancer with height and its components (leg and trunk length) in a nested case-control study and with height in a dose-response meta-analysis. Methods: We nested a case-control study within a population-based randomized controlled trial evaluating treatments for localized prostate cancer in British men ages 50 to 69 years, including 1,357 cases detected through prostate-specific antigen testing and 7,990 controls (matched on age, general practice, assessment date). Nine bibliographic databases were searched systematically for studies on the heightprostate cancer association that were pooled in a meta-analysis. Results: Based on the nested case-control, the odds ratio (OR) of prostate-specific antigen–detected prostate cancer per 10 cm increase in height was 1.06 [95% confidence interval (95% CI): 0.97-1.16; ptrend = 0.2]. There was stronger evidence of an association of height with high-grade prostate cancer (OR: 1.23; 95% CI: 1.06- 1.43), mainly due to the leg component, but not with low-grade disease (OR: 0.99; 95% CI: 0.90-1.10). In general, associations with leg or trunk length were similar. A meta-analysis of 58 studies found evidence that height is positively associated with prostate cancer (random-effects OR per 10 cm: 1.06; 95% CI: 1.03-1.09), with a stronger effect for prospective studies of more advanced/aggressive cancers (random-effects OR: 1.12; 95% CI: 1.05-1.19). Conclusion: These data indicate a limited role for childhood environmental exposures—as indexed by adult height—on prostate cancer incidence, while suggesting a greater role for progression, through mechanisms requiring further investigation.

U2 - 10.1158/1055-9965.EPI-08-0342

DO - 10.1158/1055-9965.EPI-08-0342

M3 - Article

C2 - 18768501

VL - 17(9)

SP - 2325

EP - 2336

JO - Cancer Epidemiology, Biomarkers and Prevention

JF - Cancer Epidemiology, Biomarkers and Prevention

SN - 1055-9965

ER -